Levobunolol, Hydrochloride is a non-selective β-AR (β-adrenoceptor) antagonist.
1. Kaplan, HR, et al., 1971. Oral-adrenoreceptor blocking activity of bunolol and its optical isomers. European journal of pharmacology. 16(2): 237-40. PMID: 4405784 2. DiCarlo,F.J., et al., 1977. Metabolism of I-bunolol. Clinical pharmacology & therapeutics. 22(6): 858-63. PMID: 336256
Soluble in Dimethyl Sulfoxide, Hot Ethanol, Methanol and Water
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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RothwellRothwell, CE. et al. (PubMed) evaluated the chronic toxicity and carcinogenicity of Levobunolol, a non-selective -adrenoceptor antagonist, in Swiss mice and Wistar rats. In rats, significant body weight gain suppression occurred at 5, 30, and 180 mg/kg. Brown discoloration of perianal fur and steel-gray discoloration of hairless skin were evident in high-dose rats. A generalized steel-gray discoloration of internal organs and tissues occurred in the 30 and 180 mg/kg groups. No other differences between treated and control groups were evident. -SCBT Publication Review
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