LevcromakalimAn active enantiomer of the prototypical KATP(Kir6) channel opener cromakalim

Levcromakalim (CAS 94535-50-9)

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Synonym: BRL 38227
Application: An active enantiomer of the prototypical KATP(Kir6) channel opener cromakalim
CAS Number: 94535-50-9
Molecular Weight: 286.33
Molecular Formula: C16H18N2O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Levcromakalim is an active enantiomer of the prototypical Kir6 (KATP) channel opener cromakalim.

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mM).
Storage :
Store at room temperature
Melting Point :
194.54 °C (Predicted)
Boiling Point :
482.34 °C at 760 mmHg (Predicted)
Density :
1.31 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
Optical Activity :
α20/D -66º, c = 1 in chloroform
IC50 :
Rattus norvegicus: IC50 = 40.1 nM; Cavia porcellus: IC50 = 300 nM; Sus scrofa: IC50 = 360 nM; Guinea pig trachea: IC50 = 490 nM
Ki Data :
Sulfonylurea receptor 2, Kir6.2: Ki= 1.1 µM (human)
pK Values :
pKa: 13.18 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DJ2177500
PubChem CID :
93504
MDL Number :
MFCD00864806
Beilstein Registry :
3622889
SMILES :
CC1([C@H]([C@@H](C2=C(O1)C=CC(=C2)C#N)N3CCCC3=O)O)C

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Certificate of Analysis

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Levcromakalim  Product Citations

See how others have used Levcromakalim. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28163191  Kitaguchi, T. et al. J Pharmacol Toxicol Methods. 85: 73-81.

Citations 1 to 1 of 1 total
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