Leukotriene B4-dimethyl AmideA potent lipid mediator that acts as a Leukotriene B4 antagonist

Leukotriene B4-dimethyl Amide (CAS 83024-92-4)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 61ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Application: A potent lipid mediator that acts as a Leukotriene B4 antagonist
CAS Number: 83024-92-4
Molecular Weight: 363.5
Molecular Formula: C22H37NO3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Leukotriene B4-dimethyl Amide:Leukotrienes comprise a family of endogenous metabolites of certain fatty acids and are related to thromboxanes and prostaglandins. They are potent eicosanoid lipid mediators that play numerous roles in inflammation, immunological functions and maintainin. Leukotriene B4-dimethyl Amide is an inhibitor of P2Y7. In rabbit PMNL, Leukotriene B4-dimethyl Amide can antagonize the degranulation response to LTB4.


References

1. Falcone, R.C. and Aharony, D. 1990. J. Pharmacol. Exp. Ther. 255: 565-571. PMID: 2173748
2. Showell, H.J., et al. 1982. Biochem. Biophys. Res. Commun. 106: 741-747. MID: 6288032
3. Funk, C.D. 2001. 1999. Science. 294: 1871–1875. PMID: 11729303

Formulation :
50 µg/ml in ethanol
Appearance :
Oil dissolved in ethanol
Physical State :
Liquid
Solubility :
Soluble in ethanol (~50 mg/ml), methanol, DMSO (~50 mg/ml), DMF (~50 mg/ml), and PBS (pH 7.2) (~1 mg/ml).
Storage :
Store at -80° C
Boiling Point :
78° C
Refractive Index :
n20D 1.52 (Predicted)
Ki Data :
Binding of [3H]-LTB4 to guinea pig lung membranes: Ki= 0.13 µM; LTB4-induced degranulation of human neutrophils: Ki= 0.13 µM
pK Values :
pKa: 17.72 (Predicted), pKb: -0.18 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5283126
MDL Number :
MFCD00211054
SMILES :
CCCCC/C=C\\C[C@@H](O)/C=C/C=C/C=C\\[C@@H](O)CCCC(=O)N(C)C

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 66ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 3ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.