Leu-pNA, Chromogenic Substrate CAS: 4178-93-2
MF: C12H17N3O3
MW: 251.3
An aminopeptidase substrate used to detect/evaluate functionality of aminopeptidases..

Leu-pNA, Chromogenic Substrate (CAS 4178-93-2)

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Application: Leu-pNA, Chromogenic Substrate is an aminopeptidase substrate used to detect/evaluate functionality of aminopeptidases.
CAS Number: 4178-93-2
Purity: >99%
Molecular Weight: 251.3
Molecular Formula: C12H17N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Leu-pNA, Chromogenic Substrate is a substrate for aminopeptidase, a zinc dependent enzyme that assists in the digestion of proteins. The compound has been used in an ELISA assay to detect biological functionality of chicken aminopeptidase produced by E. coli. The compound has also been used to characterize the native IRAP (placental leucine aminopeptidase). Leu-pNA, Chromogenic Substrate is documented for use with pure samples as well as cell extracts in vitro. Leu-pNA, Chromogenic Substrate is a substrate of CD13.


References

1. Bristol, L.A., et al. 1992. J. Immunol. 148: 332-338. PMID: 1345919
2. Nakanishi, Y., et al. 2000. Placenta. 21: 628-634. PMID: 10985965
3. Laeremans, H., et al. 2005. Biochem. J. 390: 351-357. PMID: 15885030
4. Yin, X., et al. 2010. Sheng Wu Gong Cheng Xue Bao. 26: 470-475. PMID: 20575434

Physical State :
Solid
Sequence :
H-L-Leu-pNA [pNA=p-nitroanilide]
Solubility :
Soluble in DMSO (>100 mM), and methanol (>25 mM).
Storage :
Store at -20° C
Melting Point :
88-90° C
Boiling Point :
~454.5° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.59
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00063681
EC Number :
224-047-3
Beilstein Registry :
2218433
SMILES :
CC(C)C[[email protected]@H](C(=O)NC1=CC=C(C=C1)[N+](=O)[O-])N

Download SDS (MSDS)

Certificate of Analysis

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Dear Technical support team, I am looking for a kit or method for determining the functionality and biological activity of Aeromonas Aminopeptidase. Is the Leu-pNA, Chromogenic Substrate product applicable for this purpose? Thank you very much.

Asked by: Soghra
Thank you for your question. We have not tested Leu-pNA, Chromogenic Substrate in such an assay.
Answered by: Tech Support Europe
Date published: 2020-09-30
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