Leptomycin B, Free AcidCAS: 87081-35-4
MF: C33H48O6
MW: 540.73
A potent nuclear export and RNA translation inhibitor.

Leptomycin B, Free Acid (CAS 87081-35-4)

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Synonym: Mantuamycin; LMB; Elactocin
Application: A potent nuclear export and RNA translation inhibitor
CAS Number: 87081-35-4
Purity: ≥98%
Molecular Weight: 540.73
Molecular Formula: C33H48O6
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Leptomycin B, Free Acid, a cytotixin and Streptomyces metabolite, has been shown to be a specific inhibitor of nuclear export signal-dependent transport via inhibition of CRM1. CRM1 is a protein required for nuclear export of proteins containing a nuclear export sequence (NES). Leptomycin B has been reported to block Rev-dependent export of mRNA into the cytoplasm, which inhibits Rev-dependent gene expression. Leptomycin B has also displayed a capacity to inhibit translation and export of many RNAs, including c-Fos and Cox-2 mRNAs, by inhibiting export of ribonucleoproteins. Additional experiments have shown leptomycin B to be an antibiotic which induces cell elongation and suppression of fission yeast. Furthermore, proliferation of rat fibroblasts was shown to be reversibly suppressed by leptomycin B in both the G1 and G2 phases, forcing the cells into a resting state (GO).


References

1. Yoshida, M., et al. 1990. Exp. Cell Res. 187: 150-156. PMID: 2298254
2. Wolff, B., et al. 1997. Chem. Biol. 4: 139-147. PMID: 9190288
3. Fukuda, M., et al. 1997. Nature. 390: 308-311. PMID: 9384386
4. Kudo, N., et al. 1999. Proc. Natl. Acad. Sci. U.S.A. 96: 9112-9117. PMID: 10430904
5. Adachi, M., et al. 2000. J. Cell Biol. 148: 849-856. PMID: 10704436

Formulation :
540 µg/mL (1 mM) in ethanol
Physical State :
Liquid
Solubility :
Soluble in ethanol or methanol. Ethanol is recommended. Unstable in DMSO
Storage :
Store at -20° C
Boiling Point :
78° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6917907
Merck Index :
13: 5463
MDL Number :
MFCD06795848
SMILES :
CCC(\\C=C\\[[email protected]@H]1OC(=O)C=C[[email protected]@H]1C)=C\\[[email protected]](C)C\\C=C\\C(C)=C\\[[email protected]@H](C)C(=O)[[email protected]@H](C)[[email protected]](O)[[email protected]@H](C)C\\C(C)=C\\C(O)=O

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Leptomycin B, Free Acid  Product Citations

See how others have used Leptomycin B, Free Acid. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 10 total

PMID: # 26131937  Krönke, J. et al. 2015. Nature. 523: 183-8.

PMID: # 25800824  Cai, W. et al. 2015. Antiviral research. 118: 82-92.

PMID: # 26140478  Sen, B. et al. 2015. Stem cells (Dayton, Ohio). 33: 3065-76.

PMID: # 25421715  Ziv, O. et al. 2014. Nature communications. 5: 5437.

PMID: # 25321479  Martin-Blanco, NM. et al. 2014. Cell Death Dis. 5: e1472.

PMID: # 24035833  Li, C. et al. 2013. Antiviral research. 100: 487-99.

PMID: # 23325696  Kalveram, B. et al. 2013. Journal of virology. 87: 3710-8.

PMID: # 22730302  Chao, HW. et al. 2012. Nucleic acids research. 40: 8484-98.

PMID: # 21543505  Kalveram, B. et al. 2011. Journal of virology. 85: 6234-43.

PMID: # 21900495  Coulonval, K. et al. 2011. Molecular biology of the cell. 22: 3971-85.

Citations 1 to 10 of 10 total

What is the potency of Leptomycin B?

Asked by: SCchem16
Leptomycin B usually exhibits IC50 values in the 1nM and depends on the species and cell type.
Answered by: Tech Service 4
Date published: 2016-12-17
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