LEF-1 Antibody (2D12): sc-81470
- LEF-1 Antibody (2D12) is a mouse monoclonal IgG1, cited in 2 publications, provided at 50 µg/0.5 ml
- raised against amino acids 1-85 of LEF-1 of human origin
- recommended for detection of LEF-1 of mouse, rat and human origin by WB and IP
- See LEF-1 (B-10): sc-374412 for LEF-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for LEF-1 Antibody (2D12). This work is in progress.
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SEE ALSO...
LEF-1 Antibody (2D12) is a mouse monoclonal IgG1 antibody that detects LEF-1 in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). LEF-1, a member of the TCF/LEF family of transcription factors, plays a crucial role in the Wnt signaling pathway, which is essential for various developmental processes and cellular functions. LEF-1 is primarily located in the nucleus, where LEF-1 interacts with β-catenin to regulate the transcription of Wnt target genes. Proper localization of LEF-1 ensures transcriptional activation of these genes occurs in response to Wnt signaling, influencing cell fate decisions and maintaining stem cell properties. Dysregulation of LEF-1 and associated pathways can lead to developmental disorders and contribute to the progression of certain cancers, highlighting the significance of studying LEF-1 in both developmental biology and cancer research. Anti-LEF-1 antibody (2D12) serves as an invaluable tool for researchers investigating the intricate mechanisms of Wnt signaling and its implications in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LEF-1 Antibody (2D12) | sc-81470 | 50 µg/0.5 ml | $322.00 |