Leelamine HClCAS: 1446-61-3
MF: C20H31N•HCl
MW: 321.9
A weak CB1 receptor agonist and PDK inhibitor.

Leelamine HCl (CAS 1446-61-3)

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Synonym: Dehydroabietylamine
Application: A weak CB1 receptor agonist and PDK inhibitor
CAS Number: 1446-61-3
Purity: ≥98%
Molecular Weight: 321.9
Molecular Formula: C20H31N•HCl
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Leelamine HCl is a diterpene compound and a weak agonist of the cannabinoid CB1 receptor. The structure of Leelamine contains no binding oxygen atoms, underscoring its weak association with the CB1 binding site. Leelamine is also described to inhibit PDK (pyruvate dehydrogenase kinase) activity.


References

1. Aicher, T.D., et al. 1999. Bioorg. Med. Chem. Lett. 9: 2223-2228. PMID: 10465550
2. Cadoudal, T., et al. 2008. Diabetes. 57: 2272-2279. PMID: 18519799
3. Lovinger, D.M. 2008. Handb Exp Pharmacol. 435-477. PMID: 18064422

Physical State :
Solid
Solubility :
Soluble in DMSO (>25 mg/ml), ethanol (>25 mg/ml), water (0.15 mg/ml) at 25° C, DMSO:PBS(pH 7.2)(1:2), and DMF.
Storage :
Store at -20° C
Melting Point :
35-38° C
Refractive Index :
n20D 1.55 (lit.)
Optical Activity :
α20/D 56.1°, c = 2.4 in pyridine
IC50 :
pyruvate dehydrogenase kinase: IC50 = 9.5 µM
Ki Data :
CB1 receptor: Ki= 5 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
TP8701000
PubChem CID :
46780578
MDL Number :
MFCD00213430
EC Number :
215-899-7
Beilstein Registry :
3084620
SMILES :
CCCC1=CC2=C(C=C1)[C@]3(CCC[C@@](C3CC2)(C)CN)C

Download SDS (MSDS)

Certificate of Analysis

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