Lavendustin CAn inhibitor of CaMKII

Lavendustin C (CAS 125697-93-0)

Lavendustin C | CAS 125697-93-0 is rated 5.0 out of 5 by 1.
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Application: An inhibitor of CaMKII
CAS Number: 125697-93-0
Purity: ≥98%
Molecular Weight: 275.3
Molecular Formula: C14H13NO5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Lavendustin C inhibits Ca2+/CaMKII (calmodulin kinase II) (IC50=0.2 μM), EGFR tyrosine kinase (IC50=44 nM) and SRC (IC50=0.5 μM). Lavendustin C also inhibits crystal-stimulated neutrophil degranulation (10-150 μM). Lavendustin C is an inhibitor of Tyk.


References

1: T.J. O'Dell et al. Nature 1991 353 558 2: T. Onada et al. J. Nat. Prod. 1989 52 1252 3. M.S. Smyth et al. J. Med. Chem. 1993 36 3010 4. H.M. Burt et al. J. Leukoc. Biol. 1994 55 112

Physical State :
Solid
Solubility :
Soluble in DMSO, methanol, and 100% ethanol.
Storage :
Store at -20° C
Melting Point :
208.34° C (Predicted)
Boiling Point :
~597.5° C at 760 mmHg (Predicted)
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.76
IC50 :
Ca2+/calmodulin kinase II: IC50 = 0.2 µM; EGF receptor tyrosine kinase: IC50 = 44 nM; Src: IC50 = 0.5 µM; pp60c-src: IC50 = 200 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
3896
MDL Number :
MFCD00153955
SMILES :
C1=CC(=C(C=C1NCC2=C(C=CC(=C2)O)O)C(=O)O)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Valle Valle-Aviles et al. (PubMed ID 18047672) used lavendustin C to inhibit budding by cells induced to re-enter the yeast cell cycle by inhibiting KN-62 in Sporothrix schenckii. -SCBT Publication Review
Date published: 2015-02-03
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