Lavendustin C inhibits Ca2+/CaMKII (calmodulin kinase II) (IC50=0.2 μM), EGFR tyrosine kinase (IC50=44 nM) and SRC (IC50=0.5 μM). Lavendustin C also inhibits crystal-stimulated neutrophil degranulation (10-150 μM). Lavendustin C is an inhibitor of Tyk.
1: T.J. O'Dell et al. Nature 1991 353 558 2: T. Onada et al. J. Nat. Prod. 1989 52 1252 3. M.S. Smyth et al. J. Med. Chem. 1993 36 3010 4. H.M. Burt et al. J. Leukoc. Biol. 1994 55 112
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ValleValle-Aviles et al. (PubMed ID 18047672) used lavendustin C to inhibit budding by cells induced to re-enter the yeast cell cycle by inhibiting KN-62 in Sporothrix schenckii. -SCBT Publication Review
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