Latrunculin A, Latrunculia magnifica CAS: 76343-93-6
MF: C22H31NO5S
MW: 421.55

Latrunculin A, Latrunculia magnifica (CAS 76343-93-6)

Latrunculin A, Latrunculia magnifica | CAS 76343-93-6 is rated 5.0 out of 5 by 2.
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Alternate Names: Latrunculin A, Latrunculia magnifica is also known as LAT-A.
Application: Latrunculin A, Latrunculia magnifica is a stabilizer of monomeric G-actin and polymerization inhibitor that disrupts microfilament organization in cultur
CAS Number: 76343-93-6
Purity: ≥96%
Molecular Weight: 421.55
Molecular Formula: C22H31NO5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Latrunculin A, Latrunculia magnifica is a macrolide toxin isolated from the red sea sponge Latrunculla magnifica. Latrunculin A, Latrunculia magnifica binds and stabilizes globular G-actin in a 1:1 complex, preventing the conversion of globular (monomeric) G-actin into filamentous (polymeric) F-actin, disturbing microfilament organization in the cell. Polymerization of G-actin and microfilament organization is essential for cellular mechanical processes including motility and cytoskeleton scaffolding, and disruption of this by Latrunculin A, Latrunculia magnifica affects normal functioning of the cell. Latrunculin A, Latrunculia magnifica was found to be able to make reversible morphological changes to mammalian cells by disrupting the actin network. Latrunculin A, Latrunculia magnifica is also known as LAT-A, NSC 613011, and (4R)-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-2-thiazolidinone.


References

1. Coué, M., et al. 1987. FEBS Lett. 213: 316-318. PMID: 3556584

2. Lyubimova, A., et al. 1999. J. Cell. Biochem. 76: 1-12. PMID: 10580995

3. Yarmola, E.G., et al. 2000. J. Biol. Chem. 275: 28120-28127. PMID: 10859320

4. Hayot, C., et al. 2006. Toxicol. Appl. Pharmacol. 211: 30-40. PMID: 16005926

5. Loubéry, S., et al. 2008. Traffic. 9: 492-509. PMID: 18194411

Physical State :
Solid
Derived From :
Latrunculia magnifica
Solubility :
Soluble in DMSO (25 mg/ml), and ethanol (25 mg/ml).
Storage :
Store at -20° C
Melting Point :
270.68° C (Predicted)
Boiling Point :
624.34° C (Predicted)
Density :
1.16 g/cm3 (Predicted)
Refractive Index :
n20D 1.53 (Predicted)
IC50 :
A549: IC50 = 142.31 nM (human); H522-T1 : IC50 = 142.31 nM; HT-29: IC50 = 142.31 nM (human); U-937: IC50 = 166.03 nM (human); MDA-MB-435: IC50 = 94.88 nM (human)
pK Values :
pKa: 11.76 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
445420
Merck Index :
14: 5378
MDL Number :
MFCD00272613
SMILES :
C[[email protected]]/1CC[[email protected]@H]2C[[email protected]](C[[email protected]@](O2)([[email protected]@H]3CSC(=O)N3)O)OC(=O)/C=C(\\CC/C=C/C=C1)/C

Download SDS (MSDS)

Certificate of Analysis

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Latrunculin A, Latrunculia magnifica (CAS 76343-93-6)  Product Citations

See how others have used Latrunculin A, Latrunculia magnifica (CAS 76343-93-6). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 23 total

PMID: # 31519880  2019. Nat Commun. 10: 4200.

PMID: # 30902980  Bertolio, R.|Napoletano, F.|Mano, M.|Maurer-Stroh, S.|Fantuz, M.|Zannini, A.|Bicciato, S.|Sorrentino, G.|Del Sal, G.| et al. 2019. Nat Commun. 10: 1326.

PMID: # 27926506  Su, L. et al. 2017. Oncotarget. 8: 2617-2627.

PMID: # 26621919  Mallol, A. et al. 2016. Reproduction. 151: 203-14.

PMID: # 26033825  Serbo, JV. et al. 2016. Adv Healthc Mater. 5: 146-58.

PMID: # 25749170  Mallol, A. et al. 2015. PLoS ONE. 10: e0120033.

PMID: # 25679223  Ito, T. et al. 2015. PLoS ONE. 10: e0118336.

PMID: # 24807265  Mutlu, N. et al. 2014. G3 (Bethesda). 4: 1247-58.

PMID: # 25068567  Mallol, A. et al. 2014. Cell Reprogram. 16: 392-406.

PMID: # 24673933  Narayanareddy, BR. et al. 2014. Traffic. 15: 762-71.

Citations 1 to 10 of 23 total

What is the solubility of this product?

Asked by: hawkeye11
Thank you for your question. Latrunculin A, Latrunculia magnifica (CAS 76343-93-6) is soluble in DMSO (25 mg/ml), and ethanol (25 mg/ml).
Answered by: Technical Support
Date published: 2017-08-19
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Rated 5 out of 5 by from The chain reaction We fully bind to the adrenal chemical enzyme and stabilize G-globular actin, catalyze the conversion of G-globular actin into filamentous F-actin, disrupting the cells in the cell tissue, detailing the catalytic chemical chain reaction
Date published: 2017-02-12
Rated 5 out of 5 by from Liu Liu, et. al. (PubMed ID 12873448) found that recovery of human trabecular meshwork (HTM) cells was quickened by treating them with latrunculin A post dexamethasone treatment/removal. -SCBT Publication Review
Date published: 2015-03-20
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