LAQ824An HDAC inhibitor affecting p21

LAQ824 (CAS 404951-53-7)

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Synonym: (E)-3-(4-(((2-(1H-indol-3-yl)ethyl)(2-hydroxyethyl)amino)methyl)phenyl)-N-hydroxyacrylamide
Application: An HDAC inhibitor affecting p21
CAS Number: 404951-53-7
Molecular Weight: 379.46
Molecular Formula: C22H25N3O3
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LAQ824 (NVP-LAQ824) is a novel HDAC inhibitor with IC50 of 32 nM. LAQ824 activates the p21 promoter with 50% of the maximal promoter activation (AC50) of 0.30 μM, which in turn, activates the p21 inhibitor gene. LAQ824 inhibits the cell growth of H1299, a non-small cell lung carcinoma line, and HCT116, a colon cancer cell line with IC50 of 0.15 μM and 0.01 μM, respectively. A recent study shows that LAQ824 induces chromatin changes at the level of the IL-10 gene promoter that lead to enhanced recruitment of the transcriptional repressors HDAC11 and PU.1 and inhibits IL-10 production in BALB/c murine macrophages.

Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6445533
SMILES :
C1=CC=C2C(=C1)C(=CN2)CCN(CCO)CC3=CC=C(C=C3)/C=C/C(=O)NO

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