LappaconitineAn analgesic alkaloid natural product

Lappaconitine (CAS 32854-75-4)

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Synonym: (+)-Lappaconitine
Application: An analgesic alkaloid natural product
CAS Number: 32854-75-4
Purity: ≥96%
Molecular Weight: 584.70
Molecular Formula: C32H44N2O8
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Lappaconitine is an alkaloid isolated from the root of Aconltitum sinomantanum Nakai. Has a strong analgesic activity that does not involve the opioid receptor. It was shown to have class-I antiarrhythmic action and irreversibly blocks cloned human heart (hH1) channels by binding to the site 2 receptor.


References

Ono, M, Satoh T. Res Comm. Chem Path Pharm. 63:13-25 (1989). Heubach JF, Schule A. Planta Medica 64:22-26 (1998). Wright SN. Mol Pharm. 59:183-192 (2001).

Physical State :
Solid
Solubility :
Soluble in benzene, alcohol (Slightly), and ether (Slightly). Insoluble in water.
Storage :
Store at 4° C
Melting Point :
217-218° C
Boiling Point :
~720.7° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
441743
SMILES :
CCN1C[C@@]2(CC[C@H](OC)[C@@]34[C@@H]5C[C@H]6[C@H](OC)[C@]5(O)[C@](O)(C[C@@H]6OC)[C@H](C[C@H]23)C14)OC(=O)C1=CC=CC=C1NC(C)=O

Download SDS (MSDS)

Certificate of Analysis

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