Lamotrigine N2-Oxide (CAS 136565-76-9)
QUICK LINKS
Lamotrigine N2-oxide is a compound used primarily in analytical chemistry research for the study of metabolic pathways and degradation profiles of lamotrigine. It serves as an important reference substance in the quantification of lamotrigine metabolites using various chromatographic and spectroscopic techniques. In environmental chemistry, Lamotrigine N2-oxide is of interest in the investigation of pharmaceutical contaminants, where researchers examine its stability and transformation products in water and soil matrices. The compound is also utilized in the field of biochemistry to explore enzyme-substrate interactions, particularly those involving oxidative enzymes that might convert lamotrigine to its N2-oxide form. Additionally, it plays a role in the study of oxidation mechanisms, offering insights into how nitrogen-containing compounds undergo metabolite formation under oxidative stress conditions in chemical systems.
Lamotrigine N2-Oxide (CAS 136565-76-9) References
- Abiotic amidine and guanidine hydrolysis of lamotrigine-N2-glucuronide and related compounds in wastewater: The role of pH and N2-substitution on reaction kinetics. | Zonja, B., et al. 2016. Water Res. 100: 466-475. PMID: 27232991
- Occurrence and fate of amisulpride, sulpiride, and lamotrigine in municipal wastewater treatment plants with biological treatment and ozonation. | Bollmann, AF., et al. 2016. J Hazard Mater. 320: 204-215. PMID: 27544733
- Simultaneous determination of 18 psychoactive agents and 6 metabolites in plasma using LC-MS/MS and application to actual plasma samples from conscription candidates. | Park, D., et al. 2018. Forensic Sci Int. 288: 283-290. PMID: 29793194
- Comparison of high resolution mrm and sequential window acquisition of all theoretical fragment-ion acquisition modes for the quantitation of 48 wastewater-borne pollutants in lettuce. | Montemurro, N., et al. 2020. J Chromatogr A. 1631: 461566. PMID: 33002708
- Biomarker responses and metabolism in Lumbricus terrestris exposed to drugs of environmental concern, an in vivo and in vitro approach. | Solé, M., et al. 2021. Chemosphere. 277: 130283. PMID: 33774234
- UDP-glucuronosyltransferase 1A4-mediated N2-glucuronidation is the major metabolic pathway of lamotrigine in chimeric NOG-TKm30 mice with humanised-livers. | Uehara, S., et al. 2021. Xenobiotica. 51: 1146-1154. PMID: 34423713
- One-step extraction and analysis of 45 contaminants of emerging concern using QuEChERS methodology and HR-MS in radish leaves and roots. | Labad, F., et al. 2021. MethodsX. 8: 101308. PMID: 34434828
- Simultaneous determination of plasma lamotrigine, lamotrigine N2-glucuronide and lamotrigine N2-oxide by UHPLC-MS/MS in epileptic patients. | Yang, H., et al. 2022. J Pharm Biomed Anal. 220: 115017. PMID: 36030754
- Occurrence, data-based modelling, and risk assessment of emerging contaminants in an alluvial aquifer polluted by river recharge. | Labad, F., et al. 2023. Environ Pollut. 316: 120504. PMID: 36283472
- An advection-reaction model of emerging contaminants in ground and surface waterbodies with known topology: a data-based approach. | Ginebreda, A., et al. 2023. MethodsX. 10: 101948. PMID: 36504498
- The Unique Human N10-Glucuronidated Metabolite Formation from Olanzapine in Chimeric NOG-TKm30 Mice with Humanized Livers. | Uehara, S., et al. 2023. Drug Metab Dispos. 51: 480-491. PMID: 36623885
- HRMS-Targeted-DIA methodology for quantification of wastewater-borne pollutants in surface water. | Gómez-Navarro, O., et al. 2023. MethodsX. 10: 102093. PMID: 36926270
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lamotrigine N2-Oxide, 5 mg | sc-471527 | 5 mg | $360.00 |