Lamivudine is a cytidine analog which acts as a potent reverse transcriptase inhibitor (nRTI). It is effective against both HIV reverse transcriptase 1 and 2, as well as hepatitis B reverse transcriptase. Lamivudine must be phosphorylated to its triphosphate form before it is active.
1. Butt, Yasmeen M., et al., . Highly active antiretroviral therapy does not affect mitochondrial beta-oxidation of fatty acids: an in vitro study in fibroblasts. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. 11(1): 35-8. PMID: 18240871 2. Kohler, James J., et al., 2009. Murine cardiac mtDNA: effects of transgenic manipulation of nucleoside phosphorylation. Laboratory investigation; a journal of technical methods and pathology. 89(2): 122-30. PMID: 19079325 3. Perez-Olmeda, M., et al., 2009. In vitro analysis of synergism and antagonism of different nucleoside/nucleotide analogue combinations on the inhibition of human immunodeficiency virus type 1 replication. Journal of medical virology. 81(2): 211-6. PMID: 19107982
Soluble in water (46 mg/ml at 25° C), DMSO (46 mg/ml at 25° C), methanol, and ethanol (<1 mg/ml at 25° C).
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Rated 5 out of
excellentWonderful and suitable for cell assay at different concentration gradients.
Date published: 2016-11-03
Rated 5 out of
Vangelotti AM; et alVangelotti AM; et al. (PubMed ID: 26411225) determined that Lamivudine in combination with ritonavir histologically altered maternal livers and kidneys in albino pregnant rats. -SCBT Publication Review
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