LamivudineA potent reverse transcriptase inhibitor

Lamivudine (CAS 134678-17-4)

Lamivudine | CAS 134678-17-4 is rated 5.0 out of 5 by 2.
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Synonym: Epivir; Zeffix; Heptovir
Application: A potent reverse transcriptase inhibitor
CAS Number: 134678-17-4
Purity: ≥99%
Molecular Weight: 229.26
Molecular Formula: C8H11N3O3S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Lamivudine is a cytidine analog which acts as a potent reverse transcriptase inhibitor (nRTI). It is effective against both HIV reverse transcriptase 1 and 2, as well as hepatitis B reverse transcriptase. Lamivudine must be phosphorylated to its triphosphate form before it is active.


References

1. Butt, Yasmeen M., et al., . Highly active antiretroviral therapy does not affect mitochondrial beta-oxidation of fatty acids: an in vitro study in fibroblasts. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. 11(1): 35-8. PMID: 18240871
2. Kohler, James J., et al., 2009. Murine cardiac mtDNA: effects of transgenic manipulation of nucleoside phosphorylation. Laboratory investigation; a journal of technical methods and pathology. 89(2): 122-30. PMID: 19079325
3. Perez-Olmeda, M., et al., 2009. In vitro analysis of synergism and antagonism of different nucleoside/nucleotide analogue combinations on the inhibition of human immunodeficiency virus type 1 replication. Journal of medical virology. 81(2): 211-6. PMID: 19107982

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (46 mg/ml at 25° C), DMSO (46 mg/ml at 25° C), methanol, and ethanol (<1 mg/ml at 25° C).
Storage :
Store at 4° C
Melting Point :
175-177° C
Boiling Point :
~475.4° C at 760 mmHg (Predicted)
Density :
~1.7 g/cm3 (Predicted)
Refractive Index :
n20D (Predicted)
Optical Activity :
α20/D -142º±5º, c = 1 in methanol
IC50 :
ADMET: IC50 = 2 nM; Human immunodeficiency virus 1: IC50 = 21.8 nM; Hepatitis B virus: IC50 = 50 nM; MT4: IC50 = 100 nM (human); Anas sp.: IC50 = 100 nM
pK Values :
pKa: 13.83 (Predicted), pKb: 9.59
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UW7361333
PubChem CID :
60825
Merck Index :
14: 5352
MDL Number :
MFCD00869739
Beilstein Registry :
5480511
SMILES :
C1[C@H](O[C@H](S1)CO)N2C=CC(=NC2=O)N

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Certificate of Analysis

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Lamivudine  Product Citations

See how others have used Lamivudine. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 24004833  Kang, LJ. et al. 2013. Int. J. Biochem. Cell Biol. 45: 2612-21.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from excellent Wonderful and suitable for cell assay at different concentration gradients.
Date published: 2016-11-03
Rated 5 out of 5 by from Vangelotti AM; et al Vangelotti AM; et al. (PubMed ID: 26411225) determined that Lamivudine in combination with ritonavir histologically altered maternal livers and kidneys in albino pregnant rats. -SCBT Publication Review
Date published: 2015-05-04
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