Anti-L-type Ca++ CP α1S Antibody (IIC12D4) is a mouse monoclonal IgG1 κ L-type Ca++ CP α1S antibody, cited in 2 publications, provided at 200 µg/ml
raised against rabbit skeletal muscle triads
recommended for detection of 170 kDa, L-type calcium channel α1S of mouse, rat, human and rabbit origin by WB, IP and IF
m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for L-type Ca++ CP α1S Antibody (IIC12D4) for WB applications. These reagents are now offered in bundles with L-type Ca++ CP α1S Antibody (IIC12D4) (see ordering information below).
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
L-type Ca++ CP α1S Antibody (IIC12D4) is a high quality monoclonal L-type Ca++ CP alpha 1S antibody (also designated L-type Ca++ CP α1S antibody) suitable for the detection of the L-type Ca++ CP alpha 1S protein of mouse, rat, human and rabbit origin. L-type Ca++ CP α1S Antibody (IIC12D4) is available as the non-conjugated anti-L-type Ca++ CP alpha 1S antibody. Voltage-dependent Ca2+ channels mediate Ca2+ entry into excitable cells in response to membrane depolarization, and they are involved in a variety of Ca2+-dependent processes, including muscle contraction, hormone or neurotransmitter release and gene expression. Calcium channels are highly diverse, multimeric complexes composed of an α-1 subunit, an intracellular β-subunit, a disulfide linked α-2/δ subunit and a transmembrane γ-subunit. Ca2+ currents are characterized on the basis of their biophysical and pharmacologic properties and include L-, N-, T-, P-, Q-, and R- types. L-type Ca2+ currents initiate muscle contraction, endocrine secretion, and gene transcription, and can be regulated through second-messenger activated protein phosphorylation pathways. L-type calcium channels may form macromolecular signaling complexes with G protein-coupled receptors, thereby enhancing the selectivity of regulating specific targets. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.