L-TetrahydropalmatineAn alkaloid that depletes neurotransmitters

L-Tetrahydropalmatine (CAS 483-14-7)

L-Tetrahydropalmatine | CAS 483-14-7 is rated 5.0 out of 5 by 1.
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Synonym: (-)-Tetrahydropalmatine
Application: An alkaloid that depletes neurotransmitters
CAS Number: 483-14-7
Purity: ≥98%
Molecular Weight: 355.43
Molecular Formula: C21H25NO4
* Refer to Certificate of Analysis for lot specific data (including water content).
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L-Tetrahydropalmatine is an alkaloid found in the plants of the Carydalis species. It depletes neurotransmitters such as dopamine, noradrenaline and serotonin. L-Tetrahydropalmatine is an inhibitor of D3DR. L-Tetrahydropalmatine is an inhibitor of SR-1A.


References

1. Liu, G.Q., et al. 1982. Arch Int Pharmacodyn Ther. 258: 39-50. PMID: 6182845
2. Lin, M.T., et al. 1996. Clin Exp Pharmacol Physiol. 23: 738-742. PMID: 8886500

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO.
Storage :
Store at room temperature
Melting Point :
147° C
Boiling Point :
482.87° C at 760 mmHg (Predicted)
Density :
1.23 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
72301
SMILES :
COC1=C(C2=C(C[C@H]3C4=CC(=C(C=C4CCN3C2)OC)OC)C=C1)OC

Download SDS (MSDS)

Certificate of Analysis

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What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. L-Tetrahydropalmatine, sc-202203, is in light yellow powder form.
Answered by: Chemical Support 4
Date published: 2017-07-05
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Rated 5 out of 5 by from Yun Yun, J (PubMed 25172791) reported that L-Tetrahydropalmatine inhibits methamphetamine-induced locomotor activity via regulation of 5-HT neuronal activity and dopamine D3 receptor expression. -SCBT Publication Review
Date published: 2015-01-19
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