L-SulforaphaneAn inducer of apoptosis, detoxification and xenobiotic enzymes

L-Sulforaphane (CAS 142825-10-3)

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Synonym: (R)-Sulforaphane; 1-Isothiocyanato-4-[(R)-methylsulfinyl]butane; (−)-Sulforaphane; (L)-Sulforaphane
Application: An inducer of apoptosis, detoxification and xenobiotic enzymes
CAS Number: 142825-10-3
Purity: 98%
Molecular Weight: 177.29
Molecular Formula: C6H11NOS2
* Refer to Certificate of Analysis for lot specific data (including water content).
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L-Sulforaphane, a compound found at high levels in broccoli, has been reported to prevent NFκB binding, which results in downregulation of apoptosis inhibitors therefore inducing apoptosis. Research has demonstrated sulforaphane to be a potent inducer of phase II detoxification enzymes and display chemoprotective properties. Other experiments have shown sulforaphane to induce enzymes of xenobiotic metabolism and therefore accelerate the metabolic disposal of xenobiotics. Sulforaphane also displays a capacity to inhibit intracellular, extracellular, and antibiotic-resistant strains of Helicobacter pylori. Additionally, this compound has been found to prevent clonogenicity. This product is sold in the L-enantiomer form.


References

1. Zhang, Y., et al. 1992. Proc. Natl. Acad. Sci. U.S.A. 89: 2399-2403. PMID: 1549603
2. Zhang, Y., et al. 1994. Proc. Natl. Acad. Sci. U.S.A. 91: 3147-3150. PMID: 8159717
3. Fahey, J.W., et al. 2002. Proc. Natl. Acad. Sci. U.S.A. 99: 7610-7615. PMID: 12032331
4. Myzak, M.C., et al. 2004. Cancer Res. 64: 5767-5774. PMID: 15313918
5. Kerns, M.L., et al. 2007. Proc. Natl. Acad. Sci. U.S.A. 104: 14460-14465. PMID: 17724334
6. Kallifatidis, G., et al. 2009. Gut. 58: 949-963. PMID: 18829980

Physical State :
Liquid
Derived From :
Synthetic source.
Solubility :
Soluble in DMSO (>5 mg/ml), 100% ethanol, methanol, chloroform, and ethyl acetate.
Storage :
Store at -20° C
Melting Point :
68.93° C (Predicted)
Boiling Point :
368.16° C at 760 mmHg (Predicted)
Density :
1.18 g/mL (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
pK Values :
pKa: -4.61 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
EK4416000
PubChem CID :
9577379
Merck Index :
14: 8962
MDL Number :
MFCD09039283
Beilstein Registry :
1723238
SMILES :
C[S@@](=O)CCCCN=C=S

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Certificate of Analysis

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L-Sulforaphane  Product Citations

See how others have used L-Sulforaphane. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 25271103  Lee, J. et al. 2015. J. Sci. Food Agric. 95: 2244-51.

Citations 1 to 1 of 1 total
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