Molecular structure of L-Sulforaphane, CAS Number: 142825-10-3
L-Sulforaphane (CAS 142825-10-3)
See product citations (3)
Alternate Names:
L-Sulforaphane is also known as R-Sulforaphane.
Application:
L-Sulforaphane is an inducer of apoptosis, phase II detoxification enzymes, and xenobiotic enzymes.
CAS Number:
142825-10-3
Purity:
≥93%
Molecular Weight:
177.29
Molecular Formula:
C6H11NOS2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-Sulforaphane, a compound found at high levels in broccoli, has been reported to prevent NFκB binding which results in downregulation of apoptosis inhibitors, therefore inducing apoptosis. Research has demonstrated L-Sulforaphane to be a potent inducer of phase II detoxification enzymes and displays chemoprotective properties. Other experiments have shown L-Sulforaphane to induce enzymes of xenobiotic metabolism and therefore accelerate the metabolic disposal of xenobiotics. L-Sulforaphane also displays a capacity to inhibit intracellular, extracellular, and antibiotic-resistant strains of Helicobacter pylori. Additionally, it has been found to prevent clonogenicity.
L-Sulforaphane (CAS 142825-10-3) References
- Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors. | Fahey, JW., et al. 2002. Proc Natl Acad Sci U S A. 99: 7610-5. PMID: 12032331
- A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. | Myzak, MC., et al. 2004. Cancer Res. 64: 5767-74. PMID: 15313918
- A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. | Zhang, Y., et al. 1992. Proc Natl Acad Sci U S A. 89: 2399-403. PMID: 1549603
- D,L-Sulforaphane-induced cell death in human prostate cancer cells is regulated by inhibitor of apoptosis family proteins and Apaf-1. | Choi, S., et al. 2007. Carcinogenesis. 28: 151-62. PMID: 16920735
- Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex. | Kerns, ML., et al. 2007. Proc Natl Acad Sci U S A. 104: 14460-5. PMID: 17724334
- Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling. | Kallifatidis, G., et al. 2009. Gut. 58: 949-63. PMID: 18829980
- Sulforaphane inhibits mitotic clonal expansion during adipogenesis through cell cycle arrest. | Choi, KM., et al. 2012. Obesity (Silver Spring). 20: 1365-71. PMID: 22282047
- Antiplatelet activity of L-sulforaphane by regulation of platelet activation factors, glycoprotein IIb/IIIa and thromboxane A2. | Oh, CH., et al. 2013. Blood Coagul Fibrinolysis. 24: 498-504. PMID: 23412354
- Cell cycle effects of L-sulforaphane, a major antioxidant from cruciferous vegetables: The role of the anaphase promoting complex. | Shelley, Z., et al. 2014. Hell J Nucl Med. 17 Suppl 1: 11-6. PMID: 24392461
- Modulating potential of L-sulforaphane in the expression of cytochrome p450 to identify potential targets for breast cancer chemoprevention and therapy using breast cell lines. | Licznerska, B., et al. 2015. Phytother Res. 29: 93-9. PMID: 25234182
- L-Sulforaphane Confers Protection Against Oxidative Stress in an In Vitro Model of Age-Related Macular Degeneration. | Dulull, NK., et al. 2018. Curr Mol Pharmacol. 11: 237-253. PMID: 29376497
- Investigation of potential anti-pneumococcal effects of l-sulforaphane and metabolites: Insights from synchrotron-FTIR microspectroscopy and molecular docking studies. | Liang, J., et al. 2020. J Mol Graph Model. 97: 107568. PMID: 32097886
- Examination of Novel Immunomodulatory Effects of L-Sulforaphane. | Mazarakis, N., et al. 2021. Nutrients. 13: PMID: 33673203
- The effects of the dietary compound L-sulforaphane against respiratory pathogens. | Mazarakis, N., et al. 2021. Int J Antimicrob Agents. 58: 106460. PMID: 34695564
- Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. | Zhang, Y., et al. 1994. Proc Natl Acad Sci U S A. 91: 3147-50. PMID: 8159717
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-Sulforaphane, 1 mg | sc-203099D | 1 mg | $143.00 | |||
L-Sulforaphane, 5 mg | sc-203099E | 5 mg | $234.00 | |||
L-Sulforaphane, 10 mg | sc-203099 | 10 mg | $418.00 | |||
L-Sulforaphane, 25 mg | sc-203099F | 25 mg | $819.00 | |||
L-Sulforaphane, 50 mg | sc-203099A | 50 mg | $1592.00 | |||
L-Sulforaphane, 100 mg | sc-203099B | 100 mg | $2560.00 | |||
L-Sulforaphane, 1 g | sc-203099C | 1 g | $20410.00 |