L-phenylephrineAn α1 adrenergic receptor agonist

L-phenylephrine (CAS 59-42-7)

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Synonym: Neosynephrine; R-(-)-Phenylephrine
Application: An α1 adrenergic receptor agonist
CAS Number: 59-42-7
Purity: ≥98%
Molecular Weight: 167.21
Molecular Formula: C9H13NO2
* Refer to Certificate of Analysis for lot specific data (including water content).
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L-phenylephrine is an α1D-AR ( α1 adrenergic receptor) agonist. L-Phenylephrine acts on alpha1-adrenergic receptors in the arterioles of the nasal mucosa to produce constriction; this leads to decreased edema and increased drainage of the sinus cavities.

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in hot methanol.
Storage :
Store at room temperature
Melting Point :
172-176° C
Boiling Point :
~341.1° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
Optical Activity :
α20D -55.5°±2.5°, c = 5 in 1mol/L HCl
IC50 :
Adrenergic receptor alpha-2: IC50 = 78 nM (rat)
Ki Data :
α2A-AR: Ki= 390 nM (human); β1-AR: Ki= 13 µM (rat); β3-AR & β1-AR: Ki= 13 µM (human)
pK Values :
pKa: 9.77 (Predicted), pKb: 9.22 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DO7175000
PubChem CID :
6041
MDL Number :
MFCD00044749
EC Number :
200-424-8
SMILES :
CNC[C@@H](C1=CC(=CC=C1)O)O

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L-phenylephrine  Product Citations

See how others have used L-phenylephrine. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28587779  Taraji, M. et al. 2017. J Chromatogr A. 1507: 53-62.

Citations 1 to 1 of 1 total
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