L-MimosineA rare plant non-protein toxic amino acid

L-Mimosine (CAS 500-44-7)

L-Mimosine | CAS 500-44-7 is rated 5.0 out of 5 by 2.
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Synonym: Leucenol
Application: A rare plant non-protein toxic amino acid
CAS Number: 500-44-7
Purity: ≥98%
Molecular Weight: 198.18
Molecular Formula: C8H10N2O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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L-Mimosine is a rare plant non-protein amino acid, chemically similar to tyrosine. It is a toxic amino acid, arresting the development of cells at the G1 phase. The synthesis of the amino acid hypusine by deoxyhypusyl hydroxylase is blocked by L-Mimosine; hypusine is necessary for the function of eIF-5A (eukaryotic initiation factor 5A), and inhibition of its synthesis leads to suspension of the cell cycle. L-Mimosine is an inhibitor of DBH, eIF5A and Tyrosinase.


References

1. Hanauske-Abel, H.M., et al. 1994. Biochim. Biophys. Acta. 1221: 115-124. PMID: 8148388
2. Hughes, T.A. and Cook, P.R. 1996. Exp. Cell Res. 222: 275-280. PMID: 8598214

Usage :
Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
Physical State :
Solid
Solubility :
Soluble in 10% NaHCO3 (15 mg/mL), water (Partly miscible), dilute acids, and bases. Insoluble in acetone, and methanol.
Storage :
Store at room temperature
Melting Point :
228° C
Refractive Index :
n20D 1.65
IC50 :
Plasmodium falciparum: IC50 = 32 µM
pK Values :
pKa: 2.06, pKb: 8.72
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UT7610000
PubChem CID :
440473
Merck Index :
14: 06199
MDL Number :
MFCD00075909
EC Number :
207-905-1
SMILES :
C1=CN(C=C(C1=O)O)C[C@@H](C(=O)O)N

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Certificate of Analysis

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L-Mimosine  Product Citations

See how others have used L-Mimosine. Click on the entry to view the PubMed entry .

Citations 1 to 8 of 8 total

PMID: # 25181960  Akcakaya, H. et al. 2015. Cell Biol. Int. 39: 201-9.

PMID: # 24158395  de la Garza-Rodea, AS. et al. 2014. FASEB J. 28: 506-19.

PMID: # 18480059  Houston, SI. et al. 2008. J. Biol. Chem. 283: 19478-19488.

PMID: # 17901051  Hyvönen, MT. et al. 2007. J. Biol. Chem. 282: 34700-34706.

PMID: # 17517622  Shu, F. et al. 2007. Proc. Natl. Acad. Sci. U.S.A. 104: 9248-9253.

PMID: # 16407229  Hopfer, U. et al. 2006. J. Biol. Chem. 281: 8645-8655.

PMID: # 9852131  Keryer, G. et al. 1998. J. Biol. Chem. 273: 34594-34602.

PMID: # 1613582  Doudet, DJ. et al. 1992. J. Nucl. Med. 33: 1383-1389.

Citations 1 to 8 of 8 total
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Rated 5 out of 5 by from Happy with purity and outcome using this chemical Happy with purity and outcome using this chemical.
Date published: 2015-08-04
Rated 5 out of 5 by from A decrease in Cdk4 protein expression was A decrease in Cdk4 protein expression was observed by WB in MDA-MB-231 cells post treatment with L-Mimosine. -SCBT QC
Date published: 2015-04-19
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