L-Kynurenine CAS: 2922-83-0
MF: C10H12N2O3
MW: 208.21
An intermediate able to suppress the antitumor immune response.

L-Kynurenine (CAS 2922-83-0)

L-Kynurenine | CAS 2922-83-0 is rated 5.0 out of 5 by 1.
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Alternate Names: 3-Anthraniloyl-L-alanine; β-Anthraniloyl-L-alanine, L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid
Application: L-Kynurenine is an intermediate able to suppress the antitumor immune response
CAS Number: 2922-83-0
Purity: ≥95%
Molecular Weight: 208.21
Molecular Formula: C10H12N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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L-Kynurenine is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppression of antitumor immune responses. It has been shown to inhibit allogeneic T-cell proliferation and to increase malignant U87 glioma cell invasion into a collagen matrix.

Physical State :
Solid
Solubility :
Soluble in 0.5 M hydrochloric acid (50 mg/ml), water (4 mg/ml at 20° C), and DMSO (50 mM).
Storage :
Store at -20° C
Melting Point :
302.49° C (Predicted)
Boiling Point :
466.56° C at 760 mmHg (Predicted)
Density :
1.34 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
Optical Activity :
α25/D -30.25°±2.25°, c = 0.4 in water; α20/D -33°, c = 0.4 in water
IC50 :
Activates the aryl hydrocarbon receptor target gene CYP1A1: EC5050 = 12.3 µM
Ki Data :
kynureninase: Ki= 4.28 µM (human)
pK Values :
pKa: 2.22 (Predicted), pKb: 7.75 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CY9049700
PubChem CID :
Merck Index :
14: 5328
MDL Number :
MFCD00069912
SMILES :
C1=CC=C(C(=C1)C(=O)CC(C(=O)O)N)N

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Certificate of Analysis

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L-Kynurenine (CAS 2922-83-0)  Product Citations

See how others have used L-Kynurenine (CAS 2922-83-0). Click on the entry to view the PubMed entry .

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PMID: # 33167329  Cells.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Sakakibara Sakakibara, K. et al. (PubMed 26318674) found that L-Kynurenine, an intermediate able to suppress the anti-tumor immune response, causes vasodilation and hypertension by voltage-dependent potassium channels in the vascular smooth muscle. -SCBT Publication Review
Date published: 2015-04-06
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