L-Cycloserine is an irreversible inhibitor of 3-ketodihydrosphingosine synthetase, which is the first enzyme of the sphingolipid pathway, and causes the synthesis of sphingolipids to decrease. In vitro studies demonstrated that L-cyloserine inhibits 3-ketodihydrosphingosine synthetase 100 times more than D-Cycloserine (sc-221470). Research regarding L-Cycloserine and its effect on the immune response suggest that L-Cycloserine increases the level of IL-4 producing helper T cells and suppress the adhesion molecules CD29 and CD98. L-Cycloserine also inhibits SPTLC (serine palmitoyltransferase (SPT)), and HIV-1 investigations in the CD4+ lymphoid cell line (CEM) have shown that L-Cycloserine can inhibit HIV-1 replication.
1. Sundaram, K.S. and Lev, M. 1984. J. Neurochem. 42: 577-581. PMID: 6693888 2. Shukla, G.S., et al. 1991. Biochim. Biophys. Acta. 1083: 101-108. PMID: 1827738 3. Mizrachi, Y., et al. 1996. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 11: 137-141. PMID: 8556395 4. Cho, J.Y. 2007. Biol. Pharm. Bull. 30: 2105-2112. PMID: 17978484
The compound is unstable in acidic or neutral solution, and stable for 1 week at 0-4°C when the aqueous solution is buffered to pH 10 with sodium carbonate.
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Cho (PubMed ID 17978484) found that LCho (PubMed ID 17978484) found that L-cycloserine, a serine palmitoyltransferase inhibitor, induced IL-4-producing helper T cells, and suppressed Mitogenic responses of splenic lymphocytes induced by LPS, PHA, and Con A. -SCBT Publication Review
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