L-755,507An enhancer of CRISPR-mediated HDR efficiency

L-755,507 (CAS 159182-43-1)

L-755,507 | CAS 159182-43-1 is rated 5.0 out of 5 by 1.
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Synonym: 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-benzenesulfonamide
Application: An enhancer of CRISPR-mediated HDR efficiency
CAS Number: 159182-43-1
Purity: ≥98%
Molecular Weight: 584.73
Molecular Formula: C30H40N4O6S
* Refer to Certificate of Analysis for lot specific data (including water content).
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L-755,507 enhances CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs). L-755,507 is also a very potent and selective β3-AR adrenergic receptor partial agonist, selective over both β1-AR and β2-AR adrenoceptor binding.


References

1. Parmee, E.R., Ok, H.O., Candelore, M.R., Tota, L., Deng, L., Strader, C.D., Wyvratt, M.J., Fisher, M.H. and Weber, A.E. 1998. Discovery of L-755,507: a subnanomolar human beta 3 adrenergic receptor agonist. Bioorg. Med. Chem. Lett. 8(9): 1107-1112. PMID: 9871717
2. Fisher, M.H., Amend, A.M., Bach, T.J., Barker, J.M., Brady, E.J., Candelore, M.R., Carroll, D., Cascieri, M.A., Chiu, S.H., Deng, L., Forrest, M.J., Hegarty-Friscino, B., Guan, X.M., Hom, G.J., Hutchins, J.E., Kelly, L.J., Mathvink, R.J., Metzger, J.M., Miller, R.R., Ok, H.O., Parmee, E.R., Saperstein, R., Strader, C.D., Stearns, R.A. and MacIntyre, D.E. 1998. A selective human beta3 adrenergic receptor agonist increases metabolic rate in rhesus monkeys. J. Clin. Invest. 101(11): 2387-2393. PMID: 9616210
3. Yu, C. et al. 2015. Cell Stem Cell. 16(2): 142-147. PMID: 25658371

Physical State :
Solid
Solubility :
Soluble to 100 mM in DMSO and to 100 mM in Ethanol
Storage :
Desiccate at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9829836
SMILES :
CCCCCCNC(=O)NC1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)CCNC[C@@H](COC3=CC=C(C=C3)O)O

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Certificate of Analysis

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L-755,507  Product Citations

See how others have used L-755,507. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 30355591  Boel, A.|De Saffel, H.|Steyaert, W.|Callewaert, B.|De Paepe, A.|Coucke, PJ.|Willaert, A.| et al. 2018. Dis Model Mech. 11:

PMID: # 29321585  Ishida, K.|Xu, H.|Sasakawa, N.|Lung, MSY.|Kudryashev, JA.|Gee, P.|Hotta, A.| et al. 2018. Sci Rep. 8: 310.

Citations 1 to 2 of 2 total

l755507在中国有没有专利问题,受不受限制。

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Rated 5 out of 5 by from We have not had any problems with this compound We have not had any problems with this compound.
Date published: 2015-03-25
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