L 748337 is a selective, competitive β3-AR (β3-adrenoceptor ) antagonist that displays selectivity over β1 and β2 receptors (Ki values are 4.0, 204 and 390 nM for β3-, β2- and β1-adrenoceptors respectively). Inhibits cAMP accumulation in response to isoproterenol (IC50 = 6 nM).
. Candelore, M.R. et al. 1999. J. Pharmacol. Exp. Ther. 290(2): 649-655. PMID: 10411574 2. Sarma, D.N. et al. 2003. J. Pharmacol. Exp. Ther. 304(1): 48-55. PMID: 12490574 3. Neidhold, S. et al. 2007. Br. J. Pharmacol. 150(3): 261-270. PMID: 17179950
Soluble in DMSO (100 mM), and ethanol (25 mM).
Store at 4° C
312.66° C (Predicted)
714.21° C (Predicted)
~1.3 g/cm3 (Predicted)
n20D 1.61 (Predicted)
α20/D -3.2°, c = 1 in ethanol; α20/D +6°±2°, c = 4 in DMSO
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Rated 5 out of
MasutaniMasutani, S. et al. (PubMed 23873794) investigated the effect of L-748,337, a selective and competitive 3-adrenoceptor antagonist, on left ventricular (LV) dynamics during exercise in dogs with pacing-induced heart failure. They found that after heart failure, L-748,337 improved LV diastolic filling; increased LV contractility, LV arterial coupling, and mechanical efficiency; improving exercise performance. -SCBT Publication Review
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