L-744,832 DihydrochlorideA Ras farnesyltransferase inhibitor that arrests cells at G1

L-744,832 Dihydrochloride (CAS 1177806-11-9)

L-744,832 Dihydrochloride | CAS 1177806-11-9 is rated 5.0 out of 5 by 1.
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Synonym: Farnesyltransferase inhibitor
Application: A Ras farnesyltransferase inhibitor that arrests cells at G1
CAS Number: 1177806-11-9
Purity: ≥98%
Molecular Weight: 632.70
Molecular Formula: C26H45N3O6S22HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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L-744,832 Dihydrochloride is a Ras Farnesyltransferase inhibitor that has been demonstrated to induce tumor regression. L-744,832 Dihydrochloride induces p21 expression and arrests cells at G1. It also causes enhanced mitotic sensitivity to taxol. Additionally, L-744,832 has been found to inhibit activation of p70 S6 kinase.


References

1: R.E. Barrington et al. Mol. Cell. Biol. 1998 18 85 2: L. Sepp-Lorenzo and N. Rosen J. Biol. Chem. 1998 273 20243 3: M.M. Moasser et al. Proc. Natl. Acad. Sci. USA 1998 95 1369

Usage :
Store solutions at -20°C for up to 3 months.
Physical State :
Solid
Solubility :
Soluble in DMSO (>25 mg/ml), and water (>15 mg/ml).
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760531
SMILES :
CC[C@@H](C)[C@@H](CO[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCS(=O)(=O)C)C(=O)OC(C)C)NC[C@H](CS)N.Cl.Cl

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Certificate of Analysis

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Rated 5 out of 5 by from Winiarska Winiarska, M. et al. (PubMed 22843692) used the Ras farnesyltransferase inhibitor, L-744,832, to demonstrate that prenyltransferases regulate CD20 protein levels and influence anti-CD20 monoclonal antibody-mediated activation of complement-dependent cytotoxicity. -SCBT Publication Review
Date published: 2015-04-03
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