L-744,832 Dihydrochloride is a Ras Farnesyltransferase inhibitor that has been demonstrated to induce tumor regression. L-744,832 Dihydrochloride induces p21 expression and arrests cells at G1. It also causes enhanced mitotic sensitivity to taxol. Additionally, L-744,832 has been found to inhibit activation of p70 S6 kinase.
1: R.E. Barrington et al. Mol. Cell. Biol. 1998 18 85 2: L. Sepp-Lorenzo and N. Rosen J. Biol. Chem. 1998 273 20243 3: M.M. Moasser et al. Proc. Natl. Acad. Sci. USA 1998 95 1369
Store solutions at -20°C for up to 3 months.
Soluble in DMSO (>25 mg/ml), and water (>15 mg/ml).
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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WiniarskaWiniarska, M. et al. (PubMed 22843692) used the Ras farnesyltransferase inhibitor, L-744,832, to demonstrate that prenyltransferases regulate CD20 protein levels and influence anti-CD20 monoclonal antibody-mediated activation of complement-dependent cytotoxicity. -SCBT Publication Review
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