L-655,708A potent and selective inverse agonist for the benzodiazepine

L-655,708 (CAS 130477-52-0)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 95ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: Ethyl (S)-11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate; L-655708
Application: A potent and selective inverse agonist for the benzodiazepine
CAS Number: 130477-52-0
Purity: ≥98%
Molecular Weight: 341.37
Molecular Formula: C18H19N3O4
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

L-655,708 is a potent and selective inverse agonist for the benzodiazepine site of GABAA R alpha5 (μ5-containing GABAA receptors). Displays high selectivity over GABAA receptors containing α1, α2, α3 or α6 subunits in combination with β3 and γ2.


References

1. Quirk, K. et al. 1996. Neuropharmacology. 35(9-10): 1331-1335. PMID: 9014149
2. Sur, C. et al. 1998. Mol. Pharmacol. 54(5): 928-933. PMID: 9804628
3. Atack, J.R. et al. 2006. Neuropharmacology. 51(6): 1023-1029. PMID: 17046030

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mM), and 1eq. HCl (10 mM). Insoluble in water.
Storage :
Desiccate at 4° C
Melting Point :
193-195° C
Boiling Point :
~584.4° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
Ki Data :
GABA receptor beta-3 subunit: Ki= 0.4 nM (human); GABA receptor gamma-2 subunit: Ki= 0.4 nM (human); GABA receptor alpha-5 subunit: Ki= 0.4 nM (human)
pK Values :
pKb: 1.50
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5311203
MDL Number :
MFCD02684528
SMILES :
CCOC(=O)C1=C2[C@@H]3CCCN3C(=O)C4=C(N2C=N1)C=CC(=C4)OC

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

What concentration should be used for in vivo rat studies?

Asked by: SCM4
This chemical, L-655,708 (CAS 130477-52-0), L-655,708 was prepared at a concentration of 5 mM in 75% saline/25% DMSO. The dose used in this study (0.7 mg/kg i.p.) was taken from the study of Martin et al (2009), in which L-655,708 was shown to reverse the amnestic properties of the anesthetic etomidate; a positive sign of its efficacy in the brain. This dose is sufficient to occupy ~70% of forebrain binding sites (Atack et al, 2005). From PMID: 25900119 Fischell, et. al. 2015. Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABAA Receptors.
Answered by: Chemical Support 1
Date published: 2017-03-24
  • y_2019, m_9, d_23, h_9CST
  • bvseo_bulk, prod_bvqa, vn_bulk_2.0.13
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_204040, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 72ms
  • QUESTIONS, PRODUCT
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 85ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.