L-4-Fluoro-phenyl-alanine CAS: 1132-68-9
MF: C9H10FNO2
MW: 183.182
A TH substrate which appears to inhibit mitosis and arrest cells in G2.

L-4-Fluoro-phenyl-alanine (CAS 1132-68-9)

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Application: L-4-Fluoro-phenyl-alanine is a TH substrate which appears to inhibit mitosis and arrest cells in G2
CAS Number: 1132-68-9
Purity: ≥99%
Molecular Weight: 183.182
Molecular Formula: C9H10FNO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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L-4-Fluoro-phenyl-alanine (p-fluoro-L-phenylalanine) is substrate for tyrosine hydroxylase (TH) that has been used to study the regulation of that enzyme. Substitution of p-fluorophenylalanine for phenylalanine in the culture medium inhibits mitosis and reversibly arrests HeLa cells in G2.


References

1. Sunkara, P S., et al., 1981. Chromosome condensing ability of mitotic proteins diminished by the substitution of phenylalanine with parafluorophenylalanine. European journal of cell biology. 23(2): 312-6. PMID: 7193581
2. Shiman, R., et al., 1994. Regulation of rat liver phenylalanine hydroxylase. I. Kinetic properties of the enzyme's iron and enzyme reduction site. The Journal of biological chemistry. 269(40): 24637-46. PMID: 7929135
3. Hillas, P J., et al., 1996. A mechanism for hydroxylation by tyrosine hydroxylase based on partitioning of substituted phenylalanines. Biochemistry. 35(22): 6969-75. PMID: 8679520

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water, and 0.5M HCl (50 mg/ml).
Storage :
Store at 4° C
Melting Point :
240° C (dec.)
Boiling Point :
~313.3° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
Optical Activity :
α24/D -5.75°±0.75°, c = 2 in 1N HCl; α20/D -25°, c = 1 in water
IC50 :
Plasmodium falciparum: IC50 = 12.59 µM
pK Values :
pKa: 2.2 (Predicted), pKb: 9.18 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DW1765000
PubChem CID :
MDL Number :
MFCD00063064
Beilstein Registry :
2416148
SMILES :
C1=CC(=CC=C1C[[email protected]@H](C(=O)O)N)F

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Certificate of Analysis

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