L-3,3prime,5-Triiodothyronine, Sodium Salt CAS: 55-06-1
MF: C15H11I3NNaO4
MW: 672.96
A compound that stimulates respiratory activity at the mitochondrial level.

L-3,3′,5-Triiodothyronine, Sodium Salt (CAS 55-06-1)

L-3,3′,5-Triiodothyronine, Sodium Salt | CAS 55-06-1 is rated 5.0 out of 5 by 1.
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Alternate Names: T3, Na; Triostat; Cytomel; Tertroxin
Application: L-3,3′,5-Triiodothyronine, Sodium Salt is a compound that stimulates respiratory activity at the mitochondrial level
CAS Number: 55-06-1
Purity: ≥99%
Molecular Weight: 672.96
Molecular Formula: C15H11I3NNaO4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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L-3,3',5-Triiodothyronine, Sodium Salt is shown to stimulate respiratory activity at the mitochondrial level.


References

1. Green, N.K., et al. 1993. Clin. Sci. 84: 61-67. PMID: 8382136
2. Lanni, A., et al. 1993. J. Endocrinol. 136: 59-64. PMID: 8381457
3. Xu, Q., et al. 1993. Eur. J. Biochem. 211: 891-898. PMID: 7916684

Physical State :
Solid
Solubility :
Soluble in water (partly miscible), dilute alkalies, 1 M HCl:EtOH (1:4) (10 mg/mL), DMSO, 100 mM NaOH (10 mg/ml), 4 M NH4OH in methanol (5 mg/ml), 1 N HCl : Alcohol mixture (1 : 2), 50% Ammonium hydroxide (20 mg/ml - clear, brown solution), 1 N Sodium hydroxide, alcohol (slightly), and ethanol 96% v/v (slightly). Practically insoluble in most other organic solvents.
Storage :
Store at room temperature
Melting Point :
205° C (dec.)
Boiling Point :
563.5° C at 760 mmHg (Predicted)
Refractive Index :
n20D ~1.76 (Predicted)
Optical Activity :
α20/D +20°, c = 1 in 1M HCl/EtOH 1:4; α22/D +21.5°, c = 2 in 1 N HCl: ethanol, 1:2; α25/D 20°±2°, c = 2 in 1.2 M HCl:EtOH (1:4)
IC50 :
Mcl-1: IC50 = 14.69 µM (human)
pK Values :
pKa: 2.13 (Predicted), pKb: 8.27 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
YP2836500
PubChem CID :
Merck Index :
14: 5510
MDL Number :
MFCD00002594
EC Number :
200-223-5
Beilstein Registry :
8179867
SMILES :
C1=CC(=C(C=C1OC2=C(C=C(C=C2I)C[[email protected]@H](C(=O)[O-])N)I)I)O.O.[Na+]

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Certificate of Analysis

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Your website states solubility in 1 M HCl:EtOH (1:4) (10 mg/mL). I have dissolved the powder in 1 M HCl:EtOH with a ratio of 1:4, based on the instructions. I would like to know that how long does it be stable in the HCl:EtOH solution at -20 °C? Do you h

Asked by: Aror
Thank you for your question. Please contact your local distributor or technical service for further assistance.
Answered by: Tech Service 1
Date published: 2021-01-21

What is the solubility of this product?

Asked by: hawkeye11
Thank you for your question. We recommend dissolving in DMSO. At room temperature, it is soluble up to 100 mg/ml. In water and ethanol, its solubility is 1 mg/ml. It is also soluble in a 1:4 mixture of HCl:EtOH at 10 mg/ml. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2019-03-13

Can I put  L-3,3′,5-Triiodothyronine, Sodium Salt to RGC culture media?

Asked by: Tianwen
Thank you for your question. This product, L-3,3′,5-Triiodothyronine, Sodium Salt: sc-205725, has not been specifically tested for cell culture use and is not cell culture grade, however, most products can still be used in cell culture applications by following basic cell culture protocols, e.g. using cell culture grade/sterilized solvents, aseptic technique, and sterilely filtering in a sterile hood. Please call our Technical Service department for further questions at (800) 457-3801 option 2, email [email protected], or contact us by live chat.
Answered by: Technical Support
Date published: 2017-05-19
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Rated 5 out of 5 by from Videla LA; et al Videla LA; et al. (PubMed ID: 22649286)Determined that L-3,3 ,5-Triiodothyronine, Sodium Salt, a nuclear factor-E2-related factor 2 (Nrf2) in rat liver, was inhibited by apocynin and greatly reduced liver Nrf2 activation and HO-1 expression. -SCBT Publication Review
Date published: 2015-07-05
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