L-3,3prime,5-Triiodothyronine, free acid CAS: 6893-02-3
MF: C15H12I3NO4
MW: 650.97
A hormone produced by the thyroid gland.

L-3,3′,5-Triiodothyronine, free acid (CAS 6893-02-3)

L-3,3′,5-Triiodothyronine, free acid | CAS 6893-02-3 is rated 5.0 out of 5 by 2.
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Alternate Names: Triiodothyronine; Tresitope
Application: L-3,3′,5-Triiodothyronine, free acid is a hormone produced by the thyroid gland
CAS Number: 6893-02-3
Purity: ≥94%
Molecular Weight: 650.97
Molecular Formula: C15H12I3NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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L-3,3′,5-Triiodothyronine, Free Acid is one of the hormones produced by the thyroid gland. L-3,3′,5-Triiodothyronine, Free Acid is also produced in peripheral tissues as the active metabolite of Thyroxine. The compound is shown to be involved in the maintenance of metabolic homeostasis.


References

1. Rodriguez, E.R., et al. 1994. Biochem. Biophys. Res. Commun. 205: 1899-1906. PMID: 7811280
2. Williams, G.R., et al. 1994. Endocrinology. 135: 2375-2385. PMID: 7988420

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in 100 mM NaOH (10 mg/ml), 4 M NH4OH in methanol (5 mg/ml). Slightly soluble in water, dilute alkalies, and ethanol. Insoluble in propylene glycol.
Storage :
Store at 4° C
Melting Point :
234-238° C (lit.)
Boiling Point :
~563.5° C at 760 mmHg (Predicted)
Density :
~2.4 g/cm3 (Predicted)
Optical Activity :
α25/D +23.0°, c = 2 in 1 N HCl: ethanol, 1:2; α20/D 23°, c = 5 in 1mol/L HCl:EtOH=1:2
IC50 :
Thyroid hormone receptor beta-1: IC50 = 4.4 nM (rat); Thyroid hormone receptor beta-1: IC50 = 0.26 nM (human); Thyroid hormone receptor alpha: IC50 = 0.24 nM (human)
Ki Data :
Thyroid hormone receptor beta-1: Ki= 0.08 nM (human); Thyroid hormone receptor alpha: Ki= 0.22 nM (human)
pK Values :
pKa: 2.13, pKb: 8.27 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
AY6750000
PubChem CID :
Merck Index :
14: 5510
MDL Number :
MFCD00002593
EC Number :
229-999-3
Beilstein Registry :
2710227
SMILES :
C1=CC(=C(C=C1OC2=C(C=C(C=C2I)C[[email protected]@H](C(=O)O)N)I)I)O

Download SDS (MSDS)

Certificate of Analysis

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What is the solubility of this product?

Asked by: hawkeye11
Thank you for your question. This chemical is soluble in 100 mM NaOH (10 mg/ml), 4 M NH4OH in methanol (5 mg/ml). Slightly soluble in water, dilute alkalies, and ethanol. Insoluble in propylene glycol. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2016-12-22
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Rated 5 out of 5 by from Exc Service Bought this 2 weeks ago and get delivered quickly.
Date published: 2020-08-14
Rated 5 out of 5 by from Videla et al Videla et al. (PubMed ID 22939323) found that the thyroid hormone, T(3), triggered the redox upregulation of cytoprotective proteins against ischemia-reperfusion liver injury by activating AMPK. -SCBT Publication Review
Date published: 2015-05-12
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