L-165041A cell permeable peroxisome proliferator activator receptor b agonist

L-165041 (CAS 79558-09-1)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 79ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: 4-[3-(2-Propyl-3-hydroxy-4-acetyl)phenoxy]propyloxyphenoxy-acetic acid
Application: A cell permeable peroxisome proliferator activator receptor b agonist
CAS Number: 79558-09-1
Purity: >98%
Molecular Weight: 402.4
Molecular Formula: C22H26O7
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

L-165041 is a cell permeable PPARβ (peroxisome proliferator-activated receptor β) agonist which induces adipocyte differentiation in NIH-PPARβ cells. In addition, this ligand reduces lipid accumulation in the liver and decreases total hepatic cholesterol and triglyceride content. Studies suggest that L-165041 affects mRNA expression by reducing the expression of PPARγ, apolipoprotein B, interleukin 1 β (IL-1β), and interleukin-6, while increasing the expression of PPARβ, lipoprotein lipase (LPL), and ATP-binding cassette transporter G1 (ABCG1). Furthermore, upon binding to PPARβ L-165041 suppresses vascular smooth muscle proliferation and migration by inhibiting the cell cycle, specifically blocking G1 to S phase progression and repressing the phosphorylation of retinoblastoma protein (Rb) in rats. Alternate studies suggest that L-165041 suppresses the cytokine-induced expression of VCAM-1 (vascular cell adhesion molecule-1) and increases UCP3 (uncoupling protein 3) gene expression in L6 myotubes. L-165041 is an activator of PPAR beta.


References

1. Leibowitz, M.D., et al. 2000. FEBS Lett. 473: 333-336. PMID: 10818235
2. Rival, Y., et al. 2002. Eur. J. Pharmacol. 435: 143-151. PMID: 11821020
3. Lim, H.J., et al. 2009. Atherosclerosis. 202: 446-454. PMID: 18585719
4. Lim, H.J., et al. 2009. Eur. J. Pharmacol. 622: 45-51. PMID: 19766624

Physical State :
Solid
Solubility :
Soluble in DMSO (>10 mg/ml), and 1 N NaOH (40 mg/ml).
Storage :
Store at 4° C
Melting Point :
127-128° C (lit.)
Boiling Point :
600.76° C at 760 mmHg (Predicted)
Density :
1.22 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
IC50 :
PPARβ: EC5050 = 125 nM (human); PPARα: EC5050 = 977 nM (human); PPARγ: EC5050 = 1.82 µM (human); Peroxisome proliferator-activated receptor delta: EC5050 = 3.8 µM (mouse); Peroxisome proliferator-activated receptor gamma: EC5050 = 10 µM (mouse)
Ki Data :
hPPARδ: Ki= 6 nM; hPPARγ: Ki= 730 nM
pK Values :
pKa: 3.23 (Predicted), pKb: -3.9 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
6603901
MDL Number :
MFCD04974501
SMILES :
CCCC1=C(C=CC(=C1O)C(=O)C)OCCCOC2=CC=C(C=C2)OCC(=O)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 57ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 19ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.