L-165041 CAS: 79558-09-1
MF: C22H26O7
MW: 402.4
A cell permeable peroxisome proliferator activator receptor b agonist.

L-165041 (CAS 79558-09-1)

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Synonym: 4-[3-(2-Propyl-3-hydroxy-4-acetyl)phenoxy]propyloxyphenoxy-acetic acid
Application: A cell permeable peroxisome proliferator activator receptor b agonist
CAS Number: 79558-09-1
Purity: >98%
Molecular Weight: 402.4
Molecular Formula: C22H26O7
* Refer to Certificate of Analysis for lot specific data (including water content).
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L-165041 is a cell permeable PPARβ (peroxisome proliferator-activated receptor β) agonist which induces adipocyte differentiation in NIH-PPARβ cells. In addition, this ligand reduces lipid accumulation in the liver and decreases total hepatic cholesterol and triglyceride content. Studies suggest that L-165041 affects mRNA expression by reducing the expression of PPARγ, apolipoprotein B, interleukin 1 β (IL-1β), and interleukin-6, while increasing the expression of PPARβ, lipoprotein lipase (LPL), and ATP-binding cassette transporter G1 (ABCG1). Furthermore, upon binding to PPARβ L-165041 suppresses vascular smooth muscle proliferation and migration by inhibiting the cell cycle, specifically blocking G1 to S phase progression and repressing the phosphorylation of retinoblastoma protein (Rb) in rats. Alternate studies suggest that L-165041 suppresses the cytokine-induced expression of VCAM-1 (vascular cell adhesion molecule-1) and increases UCP3 (uncoupling protein 3) gene expression in L6 myotubes. L-165041 is an activator of PPAR beta.


1. Leibowitz, M.D., et al. 2000. FEBS Lett. 473: 333-336. PMID: 10818235
2. Rival, Y., et al. 2002. Eur. J. Pharmacol. 435: 143-151. PMID: 11821020
3. Lim, H.J., et al. 2009. Atherosclerosis. 202: 446-454. PMID: 18585719
4. Lim, H.J., et al. 2009. Eur. J. Pharmacol. 622: 45-51. PMID: 19766624

Physical State :
Solubility :
Soluble in DMSO (>10 mg/ml), and 1 N NaOH (40 mg/ml).
Storage :
Store at 4° C
Melting Point :
127-128° C (lit.)
Boiling Point :
600.76° C at 760 mmHg (Predicted)
Density :
1.22 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
IC50 :
PPARβ: EC5050 = 125 nM (human); PPARα: EC5050 = 977 nM (human); PPARγ: EC5050 = 1.82 µM (human); Peroxisome proliferator-activated receptor delta: EC5050 = 3.8 µM (mouse); Peroxisome proliferator-activated receptor gamma: EC5050 = 10 µM (mouse)
Ki Data :
hPPARδ: Ki= 6 nM; hPPARγ: Ki= 730 nM
pK Values :
pKa: 3.23 (Predicted), pKb: -3.9 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
MDL Number :

Download SDS (MSDS)

Certificate of Analysis

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