L(+)-2-Amino-4-phosphonobutanoic acid (L-AP4) is an amino-acid derivative and a mGluR-4 and mGluR-6 metabotropic glutamate receptor agonist. L-AP4 is also an agonist at the quisqualate-sensitized AP6 site in hippocampus. L-AP4 is a potent synaptic depressant. L(+)-2-Amino-4-phosphonobutanoic acid (L-AP4) is an activator of NMDA.
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Soluble in water (25 mg/ml), dilute aqueous base, and 1eq. NaOH (100 mM).
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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TakemotoTakemoto, Y. (PubMed 25450419) reported that microinjections of L-Cysteine and the mGluR-4/6 receptor agonist L-AP4 in the rat caudal ventrolateral medulla decreases arterial blood pressure. -SCBT Publication Review
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