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KN-93 is a methoxybenzenesulfonamide that is an effective inhibitor of CaMKII (Ca2+/calmodulin-dependent protein kinase II) phosphorylating activity, and the autophosphorylation of the α- and β-subunits of CaMKII. In PC-12h cells, KN-93 has been shown to decrease phosphorylation of KCl and acetylcholine. Data suggests that KN-93 modulates the reaction rate of TH by reducing the Ca2+ mediated phosphorylation levels of TH and inhibiting dopamine formation. In rat pancreatic beta cell studies, KN-93 was shown to block insulin release, and in prostrate cancer research, KN-93 inhibited androgen receptor function and enhanced cell death independent of p53 and Akt. Research indicates that KN-93 induces G1 cell cycle arrest in both HeLa (sc-2200) and NIH 3T3 fibroblast cells (sc-2210), and causes apoptosis in NIH 3T3 cells.
1. Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181: 968-975. PMID: 1662507
2. Niki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191: 255-261. PMID: 8383489
3. Rasmussen, G., et al. 1995. Biochem. Cell Biol. 73: 201-207. PMID: 7576494
4. Tombes, R.M., et al. 1995. Cell Growth Differ. 6: 1063-1070. PMID: 8519682
5. Rokhlin, O.W., et al. 2010. Cancer Biol. Ther. 9: 224-235. PMID: 20023417
See how others have used KN-93. Click on the entry to view the PubMed entry .
PMID: # 31396050 Kim, JE.|Kang, TC.| et al. 2019. Front Mol Neurosci. 12: 180.
PMID: # 29805077 Takahashi, N.|Chen, HY.|Harris, IS.|Stover, DG.|Selfors, LM.|Bronson, RT.|Deraedt, T.|Cichowski, K.|Welm, AL.|Mori, Y.|Mills, GB.|Brugge, JS.| et al. 2018. Cancer Cell. 33: 985-1003.e7.
PMID: # 28842328 Regazzetti, C. et al. 2017. The Journal of investigative dermatology.
PMID: # 29017032 Rajan, A.|Housden, BE.|Wirtz-Peitz, F.|Holderbaum, L.|Perrimon, N.| et al. 2017. Dev. Cell. 43: 83-98.e6.
PMID: # 27864646 Yan, X. et al. 2017. Lasers Med Sci. 32: 169-180.
PMID: # 28692053 Tsoi, H. et al. 2017. Oncogene. 36: 6109-6118.
PMID: # 28971270 Shi, D. et al. 2017. Inflammation.
PMID: # 28767177 Hinrichsen, I. et al. 2017. Mol. Carcinog. 56: 2663-2668.
PMID: # 27245989 Wang, Q. et al. 2016. Autophagy. 1-15.
PMID: # 27012864 Gu, Y. et al. 2016. Leukemia.
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