KN-92A useful negative control for KN-93

KN-92 (CAS 1135280-28-2)

KN-92 | CAS 1135280-28-2 is rated 5.0 out of 5 by 1.
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Synonym: 2-[N-(4-Methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine, Phosphate
Application: A useful negative control for KN-93
CAS Number: 1135280-28-2
Purity: ≥95%
Molecular Weight: 555.0
Molecular Formula: C24H25ClN2O3S•H3PO4
* Refer to Certificate of Analysis for lot specific data (including water content).
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KN-92 is the inactive form of KN-93 (sc-202199). KN-93 is a methoxybenzenesulfonamide that is an effective inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) phosphorylating activity, and the autophosphorylation of the α- and β-subunits of CaMKII. KN-92 has been used to study CaMKII inhibitors and GluA1 AMPA receptors.


References

1. Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181: 968-975. PMID: 1662507
2. Fan, G.H., et al. 1997. Neuropharmacology. 36: 1763-1769. PMID: 9517449
3. Brooks, I.M. and Tavalin, S.J. 2010. J Biol Chem. [Epub ahead of print]. PMID: 21156788
4. Groth, R.D., et al. 2011. Proc. Natl. Acad. Sci. U.S.A. 108: 828-833. PMID: 21187407

Physical State :
Solid
Solubility :
Soluble in DMSO (6 mg/ml).
Storage :
Store at 4° C
Refractive Index :
n20D ~1.63 (Predicted)
Ki Data :
cam kinase 2: Ki= 370 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16219540
SMILES :
CN(CC=CC1=CC=C(C=C1)Cl)CC2=CC=CC=C2NS(=O)(=O)C3=CC=C(C=C3)OC.OP(=O)(O)O

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KN-92  Product Citations

See how others have used KN-92. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 29017032  Rajan, A.|Housden, BE.|Wirtz-Peitz, F.|Holderbaum, L.|Perrimon, N.| et al. 2017. Dev. Cell. 43: 83-98.e6.

PMID: # 27354537  Luster, BR. et al. 2016. Physiol Rep. 4:

PMID: # 23345405  Seward, ME. et al. 2013. J. Cell. Sci. 126: 1278-86.

PMID: # 23463379  Maubach, G. et al. 2013. International journal of cancer. Journal international du cancer. 133: 1507-12.

Citations 1 to 4 of 4 total
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Rated 5 out of 5 by from Various publications cite the use of KN Various publications cite the use of KN-92 as a negative control for KN-93 (sc-202199). KN-92 has been used to study CaMKII inhibitors and GluA1 AMPA receptors. -SCBT Publication Review
Date published: 2015-01-17
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