KL001 (CAS 309928-48-1)
Alternate Names:
N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)-methanesulfonamide
CAS Number:
309928-48-1
Molecular Weight:
398.48
Molecular Formula:
C21H22N2O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
KL001, also known as N-(3-(9H-carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide, is a small molecule that has garnered significant attention in the field of biological research. It belongs to the carbazol compound family. Moreover, it has also been the subject of exploration concerning its ability to influence the activity of diverse enzymes and proteins. Researchers have delved into its mechanism of action, although a comprehensive understanding is yet to be achieved. It is currently hypothesized that the compound binds to specific proteins, such as NF-κB. Furthermore, it is believed to modulate the activity of various enzymes, including cyclooxygenase-2 (COX-2).
KL001 (CAS 309928-48-1) References
- Identification of small molecule activators of cryptochrome. | Hirota, T., et al. 2012. Science. 337: 1094-7. PMID: 22798407
- Circadian molecular clocks and cancer. | Kelleher, FC., et al. 2014. Cancer Lett. 342: 9-18. PMID: 24099911
- C-H activation generates period-shortening molecules that target cryptochrome in the mammalian circadian clock. | Oshima, T., et al. 2015. Angew Chem Int Ed Engl. 54: 7193-7. PMID: 25960183
- Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock. | Lee, JW., et al. 2015. ChemMedChem. 10: 1489-97. PMID: 26174033
- Modulation of Circadian Rhythms Affects Corneal Epithelium Renewal and Repair in Mice. | Xue, Y., et al. 2017. Invest Ophthalmol Vis Sci. 58: 1865-1874. PMID: 28358954
- Pharmaceutical-based entrainment of circadian phase via nonlinear model predictive control. | Abel, JH., et al. 2019. Automatica (Oxf). 100: 336-348. PMID: 31673164
- Circadian control of the secretory pathway maintains collagen homeostasis. | Chang, J., et al. 2020. Nat Cell Biol. 22: 74-86. PMID: 31907414
- A Synchronized Circadian Clock Enhances Early Chondrogenesis. | Alagha, MA., et al. 2021. Cartilage. 13: 53S-67S. PMID: 32059614
- Blockade of alcohol excessive and 'relapse' drinking in male mice by pharmacological cryptochrome (CRY) activation. | Zhou, Y. and Kreek, MJ. 2021. Psychopharmacology (Berl). 238: 1099-1109. PMID: 33420591
- Chronobiotics KL001 and KS15 Extend Lifespan and Modify Circadian Rhythms of Drosophila melanogaster. | Solovev, IA., et al. 2021. Clocks Sleep. 3: 429-441. PMID: 34449576
- Effects of cryptochrome-modulating compounds on circadian behavioural rhythms in zebrafish. | Iida, M., et al. 2022. J Biochem. 171: 501-507. PMID: 34528676
- CRY2 isoform selectivity of a circadian clock modulator with antiglioblastoma efficacy. | Miller, S., et al. 2022. Proc Natl Acad Sci U S A. 119: e2203936119. PMID: 36161947
- Cryptochrome 1 activation inhibits melanogenesis and melanosome transport through negative regulation of cAMP/PKA/CREB signaling pathway. | Gao, R., et al. 2023. Front Pharmacol. 14: 1081030. PMID: 36814484
- Precise manipulation of circadian clock using MnO2 nanocapsules to amplify photodynamic therapy for osteosarcoma. | Ge, YX., et al. 2023. Mater Today Bio. 19: 100547. PMID: 36896415
- House dust mite and Th2 cytokine-mediated epithelial barrier dysfunction attenuation by KL001 in 16-HBE cells. | Duraisamy, SK., et al. 2023. Tissue Barriers. 2203841. PMID: 37079442
Inhibitor of:
BMAL1, and CRY1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KL001, 5 mg | sc-488559 | 5 mg | $72.00 | |||
KL001, 10 mg | sc-488559A | 10 mg | $198.00 | |||
KL001, 25 mg | sc-488559B | 25 mg | $292.00 |