Kinetin riboside (CAS 4338-47-0)

5.0(1)

Alternate Names: 6-Furfurylaminopurine riboside

Application: Kinetin riboside is upregulates CDKN1A, causes depletion of ATP, causes a cell cycle arrest at the G₂/M phase, and activates caspase-3

CAS Number: 4338-47-0

Purity: ≥97%

Molecular Weight: 347.33

Molecular Formula: C₁₅H₁₇N₅O₅

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

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SDS & Certificate of Analysis

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Kinetin riboside is an anti-proliferative agent which induces apoptosis in certain cell lines. Mechanistic studies show that Kinetin riboside upregulates CDKN1A, causes depletion of ATP, and causes a cell cycle arrest at the G₂/M phase. Further studies suggest that Kinetin riboside also disrupts the mitochondrial membrane potential, induces the release of cytochrome c, activates caspase-3, upregulates Bad and down-regulates Bcl-2.

References

1. Choi, B.H. et al. 2008. Cancer Lett. 261(1): 37-45. PMID: 18162289

2. Tiedemann, R.E. et al. 2008. J. Clin. Invest. 118(5): 1750-1764. PMID: 18431519

3. Cabello, C.M. et al. 2009. Biochem. Pharmacol. 77(7): 1125-1138. PMID: 19186174

4. Cheong, J. et al. 2009. Mol Biosyst. 5(1): 91-98. PMID: 19081935

Appearance :

Powder

Physical State :

Solid

Solubility :

Soluble in water (party), Acetic Acid (49-50 mg/ml), DMSO, and methanol.

Storage :

Store at 4° C

Melting Point :

152-154° C

Boiling Point :

~683.7° C at 760 mmHg (Predicted)

Density :

~1.8 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.80 (Predicted)

IC50 :

ENT1: IC₅₀ = 36.31 µM (human)

Ki Data :

Adenosine A3-R: K_i= 22 nM (human); Adenosine A2a receptor: K_i= 129 nM (rat); Adenosine A1 receptor: K_i= 236 nM (rat); Adenosine A3 receptor: K_i= 742 nM (rat)

pK Values :

pK_a: 13.11 (Predicted), pK_b: 3 (Predicted)

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

WGK Germany :

RTECS :

AU7400200

PubChem CID :

20345

MDL Number :

MFCD00037987

EC Number :

224-389-3

Beilstein Registry :

0059588

SMILES :

OC[[email protected]]1O[[email protected]]([[email protected]](O)[[email protected]@H]1O)N1C=NC2=C1N=CN=C2NCC1=CC=CO1

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Certificate of Analysis

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Is this product naturally derived or synthetic?

Asked by: frondosg

Thank you for your question. Please contact our Technical Service department by phone or email at (800)-457-3801 and [email protected]

Answered by: BlakeJ

Date published: 2022-11-14

Rated 5 out of 5 by SH from Rajabi M; et al Rajabi M; et al. (PubMed ID: 22646087) determined that Kinetin riboside caused cell cycle arrest in the S Phase by blocking through G(2)/M and G(0)/G(1) phase in HCT-15 colon cells. -SCBT Publication Review

Date published: 2015-04-19

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