Kinetin riboside CAS: 4338-47-0
MF: C15H17N5O5
MW: 347.33

Kinetin riboside (CAS 4338-47-0)

Kinetin riboside | CAS 4338-47-0 is rated 5.0 out of 5 by 1.
  • y_2021, m_6, d_12, h_18
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.17
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_221789, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 148ms
  • REVIEWS, PRODUCT
loading
5
1
4
0
3
0
2
0
1
0
Alternate Names: 6-Furfurylaminopurine riboside
Application: Kinetin riboside is upregulates CDKN1A, causes depletion of ATP, causes a cell cycle arrest at the G2/M phase, and activates caspase-3
CAS Number: 4338-47-0
Purity: ≥97%
Molecular Weight: 347.33
Molecular Formula: C15H17N5O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
loading

Kinetin riboside is an anti-proliferative agent which induces apoptosis in certain cell lines. Mechanistic studies show that Kinetin riboside upregulates CDKN1A, causes depletion of ATP, and causes a cell cycle arrest at the G2/M phase. Further studies suggest that Kinetin riboside also disrupts the mitochondrial membrane potential, induces the release of cytochrome c, activates caspase-3, upregulates Bad and down-regulates Bcl-2.


References

1. Choi, B.H. et al. 2008. Cancer Lett. 261(1): 37-45. PMID: 18162289

2. Tiedemann, R.E. et al. 2008. J. Clin. Invest. 118(5): 1750-1764. PMID: 18431519

3. Cabello, C.M. et al. 2009. Biochem. Pharmacol. 77(7): 1125-1138. PMID: 19186174

4. Cheong, J. et al. 2009. Mol Biosyst. 5(1): 91-98. PMID: 19081935

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (party), Acetic Acid (49-50 mg/ml), DMSO, and methanol.
Storage :
Store at 4° C
Melting Point :
152-154° C
Boiling Point :
~683.7° C at 760 mmHg (Predicted)
Density :
~1.8 g/cm3 (Predicted)
Refractive Index :
n20D 1.80 (Predicted)
IC50 :
ENT1: IC50 = 36.31 µM (human)
Ki Data :
Adenosine A3-R: Ki= 22 nM (human); Adenosine A2a receptor: Ki= 129 nM (rat); Adenosine A1 receptor: Ki= 236 nM (rat); Adenosine A3 receptor: Ki= 742 nM (rat)
pK Values :
pKa: 13.11 (Predicted), pKb: 3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
AU7400200
PubChem CID :
MDL Number :
MFCD00037987
EC Number :
224-389-3
Beilstein Registry :
0059588
SMILES :
OC[[email protected]]1O[[email protected]]([[email protected]](O)[[email protected]@H]1O)N1C=NC2=C1N=CN=C2NCC1=CC=CO1

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 114ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Rajabi M; et al Rajabi M; et al. (PubMed ID: 22646087) determined that Kinetin riboside caused cell cycle arrest in the S Phase by blocking through G(2)/M and G(0)/G(1) phase in HCT-15 colon cells. -SCBT Publication Review
Date published: 2015-04-19
  • y_2021, m_6, d_12, h_18
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.17
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_221789, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 13ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2021 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.