Kinetin riboside CAS: 4338-47-0
MF: C15H17N5O5
MW: 347.33

Kinetin riboside (CAS 4338-47-0)

Kinetin riboside | CAS 4338-47-0 is rated 5.0 out of 5 by 1.
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Alternate Names: 6-Furfurylaminopurine riboside
Application: Kinetin riboside is upregulates CDKN1A, causes depletion of ATP, causes a cell cycle arrest at the G2/M phase, and activates caspase-3
CAS Number: 4338-47-0
Purity: ≥97%
Molecular Weight: 347.33
Molecular Formula: C15H17N5O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
DISCOUNT: Bulk orders of Chemicals totaling $1,000 or more receive a 5% discount.
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Kinetin riboside is an anti-proliferative agent which induces apoptosis in certain cell lines. Mechanistic studies show that Kinetin riboside upregulates CDKN1A, causes depletion of ATP, and causes a cell cycle arrest at the G2/M phase. Further studies suggest that Kinetin riboside also disrupts the mitochondrial membrane potential, induces the release of cytochrome c, activates caspase-3, upregulates Bad and down-regulates Bcl-2.


References

1. Choi, B.H. et al. 2008. Cancer Lett. 261(1): 37-45. PMID: 18162289

2. Tiedemann, R.E. et al. 2008. J. Clin. Invest. 118(5): 1750-1764. PMID: 18431519

3. Cabello, C.M. et al. 2009. Biochem. Pharmacol. 77(7): 1125-1138. PMID: 19186174

4. Cheong, J. et al. 2009. Mol Biosyst. 5(1): 91-98. PMID: 19081935

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (party), Acetic Acid (49-50 mg/ml), DMSO, and methanol.
Storage :
Store at 4° C
Melting Point :
152-154° C
Boiling Point :
~683.7° C at 760 mmHg (Predicted)
Density :
~1.8 g/cm3 (Predicted)
Refractive Index :
n20D 1.80 (Predicted)
IC50 :
ENT1: IC50 = 36.31 µM (human)
Ki Data :
Adenosine A3-R: Ki= 22 nM (human); Adenosine A2a receptor: Ki= 129 nM (rat); Adenosine A1 receptor: Ki= 236 nM (rat); Adenosine A3 receptor: Ki= 742 nM (rat)
pK Values :
pKa: 13.11 (Predicted), pKb: 3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
AU7400200
PubChem CID :
MDL Number :
MFCD00037987
EC Number :
224-389-3
Beilstein Registry :
0059588
SMILES :
OC[[email protected]]1O[[email protected]]([[email protected]](O)[[email protected]@H]1O)N1C=NC2=C1N=CN=C2NCC1=CC=CO1

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Rajabi M; et al Rajabi M; et al. (PubMed ID: 22646087) determined that Kinetin riboside caused cell cycle arrest in the S Phase by blocking through G(2)/M and G(0)/G(1) phase in HCT-15 colon cells. -SCBT Publication Review
Date published: 2015-04-19
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