Kinetin ribosideUpregulates CDKN1A, causes depletion of ATP, causes a cell cycle arrest at the G2/M phase, and activates caspase-3

Kinetin riboside (CAS 4338-47-0)

Kinetin riboside | CAS 4338-47-0 is rated 5.0 out of 5 by 1.
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Synonym: 6-Furfurylaminopurine riboside
Application: Upregulates CDKN1A, causes depletion of ATP, causes a cell cycle arrest at the G2/M phase, and activates caspase-3
CAS Number: 4338-47-0
Purity: ≥98%
Molecular Weight: 347.33
Molecular Formula: C15H17N5O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Kinetin riboside is an anti-proliferative agent which induces apoptosis in certain cell lines. Mechanistic studies show that Kinetin riboside upregulates CDKN1A, causes depletion of ATP, and causes a cell cycle arrest at the G2/M phase. Further studies suggest that Kinetin riboside also disrupts the mitochondrial membrane potential, induces the release of cytochrome c, activates caspase-3, upregulates Bad and down-regulates Bcl-2.


References

1. Choi, B.H., et al. 2008. Cancer Lett. 261: 37-45. PMID: 18162289
2. Tiedemann, R.E., et al. 2008. J. Clin. Invest. 118: 1750-1764. PMID: 18431519
3. Cabello, C.M., et al. 2009. Biochem. Pharmacol. 77: 1125-1138. PMID: 19186174
4. Cheong, J., et al. 2009. Mol Biosyst. 5: 91-98. PMID: 19081935

Appearance :
Powder
Physical State :
Solid
Storage :
Store at 4° C
Melting Point :
152-154° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
20345
SMILES :
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2NCC1=CC=CO1

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Certificate of Analysis

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Rated 5 out of 5 by from Rajabi M; et al Rajabi M; et al. (PubMed ID: 22646087) determined that Kinetin riboside caused cell cycle arrest in the S Phase by blocking through G(2)/M and G(0)/G(1) phase in HCT-15 colon cells. -SCBT Publication Review
Date published: 2015-04-19
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