Keratinocyte Differentiation Inducer CAS: 863598-09-8
MF: C24H23N5O3
MW: 429.5
A cell-permeable ATP-competitive inhibitor of caseing kinase II.

Keratinocyte Differentiation Inducer (CAS 863598-09-8)

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Application: Keratinocyte Differentiation Inducer is a cell-permeable ATP-competitive inhibitor of caseing kinase II
CAS Number: 863598-09-8
Purity: 95.7%
Molecular Weight: 429.5
Molecular Formula: C24H23N5O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Keratinocyte Differentiation Inducer cell-permeable pyrrolo-pyrimidone compound that acts as a potent, ATP-competitive inhibitor of casein kinase II (IC50 = 9 nM) and an effective inducer of normal human keratinocytes (NHEK) differentiation (EC50 = 100 nM). Also reported to interact, direcly or indirectly, with cellular TANK-binding Kinase 1 (TBK1) and NIMA-related kinase 9 (NEK9).


References

1. Hong, J., et al. 2007. ACS Chem. Biol. 2: 171-175. PMID: 17348628

Physical State :
Solid
Solubility :
Soluble in ethanol, and DMSO.
Storage :
Store at 4° C
IC50 :
casein kinase II: IC50 = 9 nM; keratinocytes (NHEK) differentiation: EC5050 = 100 nM (human); Focal adhesion kinase 1: IC50 = 93 nM (human)
pK Values :
pKb: 6.14
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
COC1=CC(=CC(=C1OC)OC)NC2=NC=C3C=CN(C3=N2)C4=CC=CC(=C4)CCC#N

Download SDS (MSDS)

Certificate of Analysis

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