Keratinocyte Differentiation Inducer cell-permeable pyrrolo-pyrimidone compound that acts as a potent, ATP-competitive inhibitor of casein kinase II (IC50 = 9 nM) and an effective inducer of normal human keratinocytes (NHEK) differentiation (EC50 = 100 nM). Also reported to interact, direcly or indirectly, with cellular TANK-binding Kinase 1 (TBK1) and NIMA-related kinase 9 (NEK9).
1. Hong, J., et al. 2007. ACS Chem. Biol. 2: 171-175. PMID: 17348628