KCNQ5 Antibody (2E2): sc-293305

KCNQ5 Antibody (2E2) is a mouse monoclonal IgG2a kappa light chain antibody that detects KCNQ5 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-KCNQ5 antibody (2E2) is available as a non-conjugated format. KCNQ5 plays a crucial role in the functioning of voltage-gated potassium channels, which are essential for the repolarization of action potentials in excitable cells such as neurons and muscle cells. These channels are composed of four subunits that form a tetramer, and KCNQ5 is predominantly expressed in the brain and skeletal muscle, where KCNQ5 contributes to the regulation of neuronal excitability and muscle contraction. Notably, KCNQ5 type III, the longest splice variant, is the primary form found in skeletal muscle, highlighting KCNQ5′s importance in muscle physiology. The gene encoding KCNQ5 is located on chromosome 6q14, and while mutations in related KCNQ genes can lead to various disorders, KCNQ5 itself is not directly associated with benign familial neonatal convulsions or cardiac diseases, which are linked to mutations in KCNQ2, KCNQ1, and KCNE1. KCNQ5′s proper function is vital for maintaining the electrical stability of cells, and KCNQ5 dysregulation can have significant implications for neuronal and muscular health.

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KCNQ5 Antibody (2E2) References:

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2. A constitutively open potassium channel formed by KCNQ1 and KCNE3.  |  Schroeder, BC., et al. 2000. Nature. 403: 196-9. PMID: 10646604
3. Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity.  |  Lerche, C., et al. 2000. J Biol Chem. 275: 22395-400. PMID: 10787416
4. KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents.  |  Schroeder, BC., et al. 2000. J Biol Chem. 275: 24089-95. PMID: 10816588
5. The new voltage gated potassium channel KCNQ5 and neonatal convulsions.  |  Kananura, C., et al. 2000. Neuroreport. 11: 2063-7. PMID: 10884071
6. Cloning of a membrane protein that induces a slow voltage-gated potassium current.  |  Takumi, T., et al. 1988. Science. 242: 1042-5. PMID: 3194754
7. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias.  |  Wang, Q., et al. 1996. Nat Genet. 12: 17-23. PMID: 8528244
8. Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias.  |  Chouabe, C., et al. 1997. EMBO J. 16: 5472-9. PMID: 9312006