Kazusamycin AA potent antibiotic shown to induce G2 cell cycle arrest and delay M phase

Kazusamycin A (CAS 92090-94-3)

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Application: A potent antibiotic shown to induce G2 cell cycle arrest and delay M phase
CAS Number: 92090-94-3
Purity: 95%
Molecular Weight: 556.7
Molecular Formula: C33H48O7
* Refer to Certificate of Analysis for lot specific data (including water content).
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Kazusamycin A is a potent antibiotic with strong antifungal activity that is produced by actinomycete. Urological cancer cell research reports that Kazusamycin A induces G2 cell cycle arrest and delays the M phase. Studies demonstrate that Kazusamycin A shows high cytotoxic activity against HeLa cells in vitro and lacks activity against gram negative and gram positive bacteria. Additionally, HIV-1 investigations indicate that the Kazusamycin family inhibits the translocation of the regulatory protein Rev from the nucleus to the cytoplasm.


References

1. Vanderhoeft, P., et al. 1965. Acta Chir. Belg. 64: 1195-1210. PMID: 5330629
2. Umezawa, I., et al. 1984. J. Antibiot. 37: 706-711. PMID: 6432763
3. Komiyama, K., et al. 1985. J. Antibiot. 38: 224-229. PMID: 3922935
4. Tunac, J.B., et al. 1985. J. Antibiot. 38: 460-465. PMID: 3924872
5. Sawamura, M., 1992. Nippon Hinyokika Gakkai Zasshi. 83: 627-635. PMID: 1495200
6. Wolff, B., et al. 1997. Chem. Biol. 4: 139-147. PMID: 9190288

Appearance :
Film
Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in ethanol, methanol, DMSO, and DMF. Insoluble in water.
Storage :
Store at -20° C
Boiling Point :
761.45° C at 760 mmHg (Predicted)
Density :
1.11 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
pK Values :
pKa: 5.1 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
RTECS :
OA0550000
PubChem CID :
5477877
MDL Number :
MFCD03265635
EC Number :
200-659-6
SMILES :
CC/C(=C\\C(C)C/C=C/C(=C/C(CO)C(=O)C(C)C(C(C)C/C(=C/C(=O)O)/C)O)/C)/C=C/C1C(C=CC(=O)O1)C

Download SDS (MSDS)

Certificate of Analysis

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