Kasugamycin Hydrochloride Monohydrate CAS: 6980-18-3
MF: C14H25N3O9•HCl•H2O
MW: 433.84
An aminoglycoside antibiotic that blocks translation initiation.

Kasugamycin Hydrochloride Monohydrate (CAS 6980-18-3)

Kasugamycin Hydrochloride Monohydrate | CAS 6980-18-3 is rated 5.0 out of 5 by 1.
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Alternate Names: 3-O-[2-amino-4-[(carboxyiminomethyl)amino]-2,3,4,6-tetradeoxy-α-D-arabino-hexopyranosyl]-D-chiro-inositol Hydrochloride Monohydrate
Application: Kasugamycin Hydrochloride Monohydrate is an aminoglycoside antibiotic that blocks translation initiation
CAS Number: 6980-18-3
Purity: ≥84%
Molecular Weight: 433.84
Molecular Formula: C14H25N3O9•HCl•H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Kasugamycin is an aminoglycoside antibiotic that potently inhibits both gram-positive and gram-negative bacteria and blocks translation initiation. To a weaker extent, Kasugamycin also inhibits phytopathogenic microbes. Research shows that Kasugamycin can associate with the 30s ribosomal subunit, which results in the indirect inhibition of the P-site tRNA binding, and blocks protein synthesis.


References

1. Umezawa, H., et al. 1965. J. Antibiot. 18: 101-103. PMID: 14326080
2. Chattopadhyay, S., et al. 1999. Biochim. Biophys. Acta. 1429: 293-298. PMID: 9989214
3. Tamamura, T. and Sato, K. 1999. Jpn J Antibiot. 52: 57-67. PMID: 10202688
4. Moll, I., et al. 2002. Biochem. Biophys. Res. Commun. 297: 1021-1026. PMID: 12359258
5. Schluenzen, F., et al. 2006. Nat. Struct. Mol. Biol. 13: 871-878. PMID: 16998488
6. Surkov, S., et al. 2010. FEBS J. 277: 2428-2439. PMID: 20477873

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water.
pH :
5.41
Storage :
Store at -20° C
Melting Point :
202-230° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
57369825
MDL Number :
MFCD00058459

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Certificate of Analysis

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PMID: # 23804760  Guja, KE. et al. 2013. Nucleic Acids Res. 41: 7947-59.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Alexander A Alexander A.; et. al. (PubMed ID: 6049299 ) demonstrated that Kasugamycin Hydrochloride Monohydrate did not target pseudomonas, as previous articles have claimed. -SCBT Publication Review
Date published: 2015-04-30
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