karyopherin β2/2B Antibody (A-11) is a mouse monoclonal IgG1 (kappa light chain) provided at 200 µg/ml
specific for an epitope mapping between amino acids 2-29 at the N-terminus of karyopherin β2 of human origin
karyopherin beta 2/2B Antibody (A-11) is recommended for detection of karyopherin β2 and karyopherin β2B of mouse, rat, human and avian origin by WB, IP, IF and ELISA; also reactive with additional species, including bovine and avian
karyopherin beta 2/2B Antibody (A-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
blocking peptide, sc-365179 P
See m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP), our highly recommended recombinant alternative to conventional secondary anti-mouse IgG reagents.
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of karyopherin β2/2B (A-11): sc-365179.
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
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Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Protein transport across the nucleus is a selective, multi-step process involving several cytoplasmic factors. Proteins must be recognized as import substrates, dock at the nuclear pore complex and translocate across the nuclear envelope in an ATP-dependent fashion. Two cytosolic factors centrally involved in the recognition and docking process are the karyopherin α1 and karyopherin β1 subunits. Karyopherin α1 functions in the recognition and targeting of substrates destined for nuclear import, while karyopherin β1 serves as an adapter, tethering the karyopherin α1/substrate complex to docking proteins on the nuclear envelope, termed nucleoporins. Karyopherin α2 has been shown to complex with Epstein-Barr virus nuclear antigen 1 (EBNA-1). Karyopherin β2 and karyopherin β2B (also designated transportin 1 and transportin 2) share 84% sequence identity at the amino acid level, however, they have been shown to have different substrate specificities. Karyopherin β2 mediates hnRNPA1 nuclear import while karyopherin β2B has been implicated in the export of cellular mRNAs through complexes formed with the mRNA export factor TAP.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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