K-252bCAS: 99570-78-2
MF: C26H19N3O5
MW: 453.45
An antibiotic and a strong inhibitor of protein kinase C (PKC).

K-252b (CAS 99570-78-2)

K-252b | CAS 99570-78-2 is rated 5.0 out of 5 by 1.
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Synonym: Staurosporine Aglycone
Application: An antibiotic and a strong inhibitor of protein kinase C (PKC)
CAS Number: 99570-78-2
Purity: ≥98%
Molecular Weight: 453.45
Molecular Formula: C26H19N3O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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K-252b is a general, cell permeable protein kinase inhibitor which acts by binding to the ATP binding domain of the kinase. K-252b is a potent inhibitor of CaMKII (Ca2+/calmodulin kinase II), MYLK (myosin light chain kinase, Ki=0.147 μM), PKA (cAMP- dependent protein kinase, Ki=0.09 μM), PKC (protein kinase C, Ki=0.02 μM), and cGKI (cGMP-dependent protein kinase, Ki=0.1 μM).


References

1. Nakanishi, S., et al. 1986. J. Antibiot. 39: 1066-1071. PMID: 3759658
2. Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142: 436-440. PMID: 3028414
3. Knüsel, B. and Hefti, F. 1991. J. Neurochem. 57: 955-962. PMID: 1861160
4. Teshima, R., et al. 1997. J. Immunol. 159: 964-969. PMID: 9218617
5. Pong, K., et al. 1997. J. Neurochem. 69: 986-994. PMID: 9282920
6. Fujii, S., et al. 2002. Neuroscience. 113: 617-628. PMID: 12150781

Physical State :
Solid
Solubility :
Soluble in DMSO (1 mg/ml), DMF (1 mg/ml), and methanol (2 mg/ml).
Storage :
Store at -20° C
Melting Point :
318.16° C (Predicted)
Boiling Point :
~769.8° C at 760 mmHg (Predicted)
Density :
~1.8 g/cm3 (Predicted)
Refractive Index :
n20D 1.903
IC50 :
Protein kinase C zeta: IC50 = 38 nM (Homo sapiens); Protein kinase C delta: IC50 = 38 nM (Homo sapiens); Protein kinase C eta: IC50 = 38 nM (Homo sapiens); Protein kinase C mu: IC50 = 38 nM (Homo sapiens); Protein kinase C gamma: IC50 = 38 nM (Homo sapiens); Protein kinase C beta: IC50 = 38 nM (Homo sapiens); Protein kinase C nu: IC50 = 38 nM (Homo sapiens); Protein kinase C alpha: IC50 = 38 nM (Homo sapiens); Protein kinase C theta: IC50 = 38 nM (Homo sapiens); Protein kinase C epsilon: IC50 = 38 nM (Homo sapiens); Protein kinase C iota: IC50 = 38 nM (Homo sapiens)
Ki Data :
myosin light chain kinase(MLCK): Ki= 0.15 µM; cAMP- dependent protein kinase(PKA): Ki= 0.09 µM; protein kinase C(PKC): Ki= 0.02 µM; cGMP-dependent protein kinase(PKG): Ki= 0.1 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9846716
MDL Number :
MFCD09878299
SMILES :
C[[email protected]@]12[[email protected]@](CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)O)O

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K-252b  Product Citations

See how others have used K-252b. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 16699962  Lautrette, C. et al. 2006. Apoptosis. 11: 1195-1204.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Using this for a few different experiments Using this for a few different experiments and it is working well!
Date published: 2015-05-18
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