K 185 MF: C24H28N2O2
MW: 376.49
A melatonin receptor antagonist.

K 185

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Alternate Names: N-Butanoyl 2-(5,6,7-trihydro-11-methoxybenzo[c]cyclohept[2,1-a]indol-13-yl)ethanamine
Application: K 185 is a melatonin receptor antagonist
Molecular Weight: 376.49
Molecular Formula: C24H28N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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K 185 is a MEL-1 (melatonin receptor) antagonist.


References

1. Faust, R., et al. 2000. J. Med. Chem. 43: 1050-1061. PMID: 10737738

Physical State :
Solid
Solubility :
Soluble in DMSO (20 mg/ml).
Storage :
Store at -20° C
Melting Point :
248.09° C (Predicted)
Boiling Point :
~654.2° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
IC50 :
Agonistic activity against melatonin of Xenopus melanophores: IC50 = 525 nM
Ki Data :
MEL-1B-R: Ki= 0.5 nM (human); MEL-1A-R: Ki= 66 nM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD03790885
SMILES :
CCCC(=O)NCCC1=C2C3=CC=CC=C3CCCN2C4=C1C=C(C=C4)OC

Download SDS (MSDS)

Certificate of Analysis

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