JP 1302 dihydrochloride CAS: 80259-18-3
MF: C24H24N4•2HCl
MW: 441.4
A selective α2C-AR.

JP 1302 dihydrochloride (CAS 80259-18-3)

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Alternate Names: N-(4-(4-methylpiperazin-1-yl)phenyl)acridin-9-amine dihydrochloride
Application: JP 1302 dihydrochloride is a selective α2C-AR
CAS Number: 80259-18-3
Purity: ≥99%
Molecular Weight: 441.4
Molecular Formula: C24H24N42HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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JP 1302 dihydrochloride is a potent and selective α2C-AR adrenoreceptor antagonist. JP 1302 dihydrochloride strongly antagonizes adrenaline-stimulated 35GTPγS binding in vitro.


References

Tricklebank (2007) JP-1302: a new tool to shed light on the roles of a2C-adrenoceptors in brain. Br.J.Pharmacol. 150 381. Sallinen et al (2007) Pharmacological characterization and CNS effects of a novel highly selective a2C-adrenoceptor antagonist JP-1302. Br.J.Pharmacol. 150 391.

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mM), and water (100 mM).
Storage :
Desiccate at -20° C
Refractive Index :
n20D 1.71
Ki Data :
α2C-AR: Ki= 28 nM (human); α2B-AR: Ki= 1.47 µM (human); α2D-adrenoceptor : Ki= 1.70 µM (human); α2A-AR: Ki= 3.15 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
AR7147000
PubChem CID :
SMILES :
CN1CCN(CC1)C2=CC=C(C=C2)NC3=C4C=CC=CC4=NC5=CC=CC=C53.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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