JNK Inhibitor XIVA selective JNK1, JNK2, and JNK3 inhibitor

JNK Inhibitor XIV

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Synonym: SR-3306; N-(4-(3-(6-Methylpyridin-3-yl)-1H-1,2,4-triazol-1-yl)phenyl)-4-(3-morpholinophenyl)pyrimidin-2-amine
Application: A selective JNK1, JNK2, and JNK3 inhibitor
Purity: ≥95%
Molecular Weight: 490.56
Molecular Formula: C28H26N8O
* Refer to Certificate of Analysis for lot specific data (including water content).
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JNK Inhibitor XIV is a cell-permeable and blood-brain-barrier-permeant anilinopyrimidine compound that acts as a highly selective, potent, reversible, and ATP-competitive JNK inhibitor (IC50 = 67, 283, and 159 nM against JNK1, JNK2, and JNK3, respectively).

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO.
Storage :
Store at 4° C
IC50 :
JNK1: IC50 = 67 nM; JNK3: IC50 = 159 nM; JNK2: IC50 = 283 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
57519510
SMILES :
CC1=NC=C(C=C1)C2=NN(C=N2)C3=CC=C(C=C3)NC4=NC=CC(=N4)C5=CC(=CC=C5)N6CCOCC6

Download SDS (MSDS)

Certificate of Analysis

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