JNK Inhibitor V is a potent and cell permeable ATP competitive JNK inhibitor (hJNK1: IC50 = 150nM, hJNK2: IC50 = 220nM and hJNK3: IC50 = 70 nM). Experiments have reported JNK signaling pathway to play a role in ischemia-induced cell death in hippocampal CA1 neurons in a gerbil model. Therefore, preventing the activation of JNK has the potential of being neuroprotective. Additionally, in murine studies, the compound has been observed to reduce infarct size caused by myocardial ischemia. JNK Inhibitor V has also been noted to display anti-inflammatory capacities.
1. Ferrandi, C., et al. 2004. Br. J. Pharmacol. 142: 953-960. PMID: 15210584 2. Carboni, S., et al. 2004. J. Pharmacol. Exp. Ther. 310: 25-32. PMID: 14988419 3. Gaillard, P., et al. 2005. J. Med. Chem. 48: 4596-4607. PMID: 15999997
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WuWu, J. et al. (PubMed 26362062) used the JNK Inhibitor V to demonstrate that activation of SAPK/JNK mediated the inhibition and reciprocal interaction of DNA methyltransferase 1 and EZH2 by ursolic acid in human lung cancer cells. -SCBT Publication Review
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