JNJ-26481585An HDAC1, HDAC2, HDAC4, HDAC10, and HDAC11 inhibitor

JNJ-26481585 (CAS 875320-29-9)

JNJ-26481585 | CAS 875320-29-9 is rated 5.0 out of 5 by 1.
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Synonym: Quisinostat
Application: An HDAC1, HDAC2, HDAC4, HDAC10, and HDAC11 inhibitor
CAS Number: 875320-29-9
Molecular Weight: 394.5
Molecular Formula: C21H26N6O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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JNJ-26481585 (Quisinostat) is an HDAC inhibitor. It has a second generation histone deacetylase inhibitor with antineoplastic activities. It inhibits well for HDAC1 (IC50 = 0.11 nM), HDAC2 (IC50 = 0.33 nM), HDAC4 (IC50 = 0.64 nM), HDAC10 (IC50 = 0.46 nM), HDAC11 (IC50 = 0.37 nM).

Physical State :
Solid
Solubility :
Soluble in DMSO (79 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), and 15% Captisol (30 mg/ml at 25 °C).
Storage :
Store at -20° C
Melting Point :
276.22° C (Predicted)
Boiling Point :
636.19° C (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
IC50 :
HDAC1: IC50 = 0.11 nM; HDAC2: IC50 = 0.33 nM; HDAC11: IC50 = 0.37 nM; HDAC10: IC50 = 0.46 nM; HDAC4: IC50 = 0.64 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
11538455
SMILES :
CN1C=C(C2=CC=CC=C21)CNCC3CCN(CC3)C4=NC=C(C=N4)C(=O)NO

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Certificate of Analysis

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Rated 5 out of 5 by from Schreml Schreml, J. et al. (PubMed 23073311) reported that severe spinal muscular atrophy mice show organ impairment that cannot be rescued by therapy with the HDAC inhibitor JNJ-26481585. -SCBT Publication Review
Date published: 2015-07-02
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