JNJ 17203212

JNJ 17203212 (CAS 821768-06-3)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 106ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: 4-[3-(TRIFLUOROMETHYL)-PYRIDIN-2-YL]-N-[5-(TRIFLUOROMETH YL)-PYRIDIN-2-YL]-1-PIPERAZINECARBOXAMIDE
Application: A high affinity TRPV1 receptor antagonist
CAS Number: 821768-06-3
Purity: ≥98%
Molecular Weight: 419.33
Molecular Formula: C17H15F6N5O
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

JNJ 17203212 is a high affinity transient receptor potential vanilloid 1 (TRPV1) receptor antagonist. TRPV1 is a Capsaicin (sc-3577) receptor that behaves as a non-selective cation channel that is mainly found in the sensory neurons, and specifically detects painful stimuli, low pH and heat. The compound has been used to investigate TRPV1 in rodent and guinea pig sensory reflexes. Research indicates that JNJ 17203212 elevates the micturition reflex threshold for activation in rodent bladder studies, and in rats weakens colonic hypersensitivity.


References

1. Swanson, D.M., et al. 2005. J. Med. Chem. 48: 1857-1872. PMID: 15771431
2. Ghilardi, J.R., et al. 2005. J. Neurosci. 25: 3126-3131. PMID: 15788769
3. Bhattacharya, A., et al. 2007. J. Pharmacol. Exp. Ther. 323: 665-674. PMID: 17690251
4. Cefalu, J.S., et al. 2009. J. Urol. 182: 776-785. PMID: 19539322
5. Schumacher, M.A. and Eilers, H. 2010. Front. Biosci. 15: 872-882. PMID: 20515731
6. Wiskur, B.J., et al. 2010. Methods Find Exp Clin Pharmacol. 32: 557-564. PMID: 21132125

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (100 mM).
Storage :
Store at -20° C
Melting Point :
89.4-89.8° C
Boiling Point :
551.32° C at 760 mmHg (Predicted)
Density :
1.47 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
IC50 :
Vanilloid receptor: IC50 = 16 nM (rat); VR1: IC50 = 16 nM (human); BJP: IC50 = 65 nM
pK Values :
pKa: 12.62 (Predicted), pKb: 5.99 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
11339118
SMILES :
C1CN(CCN1C2=C(C=CC=N2)C(F)(F)F)C(=O)NC3=NC=C(C=C3)C(F)(F)F

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 95ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 28ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.