JMV3002

JMV3002 (CAS 925239-03-8)

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Application: A strong ghrelin receptor antagonist
CAS Number: 925239-03-8
Molecular Weight: 586.70
Molecular Formula: C35H34N6O3
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* Refer to Certificate of Analysis for lot specific data (including water content).
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JMV3002 is a strong ghrelin receptor antagonist with an IC50 value of 1.1 nM in vitro.1 At 80 µg/kg, JMV3002 inhibits hexarelin-stimulated food intake by as much as 98% in rats.1 JMV3002 alone does not elicit growth hormone release nor does it inhibit hexarelin-stimulated growth hormone secretion when tested in infant rats at a dose of 160 µg/kg.


References

1 Moulin, A., Demange, L., Ryan, J., et al. New trisubstituted 1,2,4-triazole derivatives as potent ghrelin receptor antagonists. 3. Synthesis and pharmacological in vitro and in vivo evaluations. J Med Chem 51 689-693 (2008).

Formulation :
A solution in methyl acetate
Physical State :
Liquid
Storage :
Store at -20° C
Boiling Point :
57° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Transport :
UN 1231, Class 3, Packing group II
PubChem CID :
53394052
SMILES :
COC1=CC(=C(C=C1)C[N]2C(=NN=C2C(NC(=O)C3=NC=CC=C3)CC4=C[N]C5=C4C=CC=C5)CCC6=CC=CC=C6)OC

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Certificate of Analysis

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